1.
Br J Haematol
; 142(1): 79-81, 2008 Jul.
Article
in English
| MEDLINE
| ID: mdl-18422778
ABSTRACT
The ubiquitous herpesvirus Epstein-Barr virus (EBV) is linked to the development of several malignancies, including nasopharyngeal carcinoma (UCNT) and Hodgkin lymphoma (HL). Despite the well-known oncogenic properties of the EBV latent membrane protein 1 (LMP-1), the different oncogenic pathways involved in the pathogenesis of each disease remain unclear. This study reported, for the first time, the case of a patient with sequential development of UCNT and HL. Polymerase chain reaction was used to determine the LMP-1 gene sequence and demonstrate that the two tumours contained different clonal viral genomes, suggesting a central and specific role of EBV infection.
Subject(s)
Epstein-Barr Virus Infections/genetics , Herpesvirus 4, Human/genetics , Hodgkin Disease/genetics , Nasopharyngeal Neoplasms/genetics , Neoplasms, Second Primary/genetics , Viral Matrix Proteins/genetics , Adult , Hodgkin Disease/virology , Humans , Male , Nasopharyngeal Neoplasms/virology , Neoplasms, Second Primary/virology , Nucleic Acid Amplification Techniques , Polymerase Chain Reaction
2.
Acta Clin Belg
; 56(3): 191-4, 2001.
Article
in English
| MEDLINE
| ID: mdl-11484517