ABSTRACT
In a prospective randomized study, the clinical effectiveness of ciprofloxacin at a single dose of 250 mg p.o. was compared with that of two oral doses of 250 mg bid administered for two days in women with urinary tract infection following gynecological procedures. A healing rate of 95% was achieved with both single-dose (n = 62) and two-day treatment (n = 65). In a further prospective randomized multicenter study, single-dose therapy with 250 mg of oral ciprofloxacin in women with uncomplicated urinary tract infection was compared with three days of ambulatory treatment with 2 x 250 mg/day. In the case of these patients, the diagnosis was made and treatment applied in the doctor's office by one of seven specialist gynecologists practicing in the city area of Essen. The healing rate of 78% (n = 46) achieved with single-dose treatment was significantly inferior to the 91% seen with the three-day regimen (n = 53, p < 0.05).
Subject(s)
Ciprofloxacin/administration & dosage , Urinary Tract Infections/drug therapy , Adult , Drug Administration Schedule , Female , Humans , Hysterectomy , Middle Aged , Postoperative Complications/drug therapy , Prospective Studies , Urinary CatheterizationABSTRACT
In a prospective randomized multicenter study Roxithromycin 150 mg or Doxycycline 100 mg was given b.i.d. p.o. for ten days to women with clinically diagnosed cervicitis. All women were seen as outpatients by one of eight licensed gynecologists in their private office in the Essen city area. With a cure and improvement rate of 100% in those women who completed therapy, Roxithromycin (n = 106) was as effective as Doxycycline (n = 104; 98%). At 90% Roxithromycin was as well tolerated as Doxycycline at 93%. Both drugs were clinically and microbiologically effective in eradicating Chlamydia trachomatis.
