ABSTRACT
BACKGROUND AND PURPOSE: While survival times after treatment of medulloblastoma are increasing, little is known about radiochemotherapy (RCT)-induced cerebrovascular changes. High resolution vessel wall imaging (VWI) sequences are an emerging tool for the evaluation of cerebrovascular diseases. We performed VWI in medulloblastoma long-term survivors to screen for late sequelae of RCT. MATERIAL AND METHODS: Twenty-two pediatric medulloblastoma survivors (mean age 25.8â¯years (10-53â¯years); 16.3â¯years (mean) post primary RCT (range 1-45â¯years)) underwent 2D VWI-MRI. Vessel wall thickening, contrast enhancement and luminal narrowing were analyzed. The findings were correlated with the patients' radiation protocols. RESULTS: Vessel wall changes were observed the intracranial internal carotid artery (ICA) and the vertebrobasilar circulation (VBC) in 14 of 22 patients (63.6%). In multivariate analysis, time after RCT (ORâ¯=â¯1.38, pâ¯<â¯0.05) was strongest independent predictor for development of vessel wall alterations. The dose of radiation was not a relevant predictor. CONCLUSIONS: With longer follow-up time intracranial vessel wall changes are observed more frequently in medulloblastoma survivors. Thus VWI is a useful tool to monitor vessel wall alterations of cranially irradiated patients, creating the prerequisite for further treatment of late sequelae.
Subject(s)
Carotid Artery, Internal/radiation effects , Cerebellar Neoplasms/radiotherapy , Cerebral Arteries/radiation effects , Cerebrovascular Circulation/radiation effects , Medulloblastoma/radiotherapy , Adolescent , Cancer Survivors , Carotid Artery Diseases/diagnostic imaging , Carotid Artery Diseases/etiology , Carotid Artery, Internal/diagnostic imaging , Cerebellar Neoplasms/diagnostic imaging , Cerebellar Neoplasms/drug therapy , Cerebral Arteries/diagnostic imaging , Child , Child, Preschool , Cranial Irradiation/adverse effects , Cranial Irradiation/methods , Female , Humans , Intracranial Arteriosclerosis/diagnostic imaging , Intracranial Arteriosclerosis/etiology , Magnetic Resonance Angiography , Magnetic Resonance Imaging/methods , Male , Medulloblastoma/diagnostic imaging , Medulloblastoma/drug therapy , Radiation Injuries/diagnostic imaging , Radiation Injuries/etiologyABSTRACT
BACKGROUND AND PURPOSE: Due to sensitive neuroimaging techniques, cerebrovascular complications such as cerebral microbleeds (CMB) and cerebral cavernous malformations (CCM) are increasingly recognized as considerable late effects after treatment for pediatric brain tumor. The aim of this study was to analyze CMB in a cohort of patients after cranial irradiation therapy for medulloblastoma or other pediatric brain tumors using susceptibility-weighted magnetic resonance imaging (SWI). MATERIALS AND METHODS: Forty former pediatric brain tumor patients were enrolled in this prospective cross-sectional study and examined by cranial MRI including SWI sequences. Cerebral microbleeds, clinical symptoms and disability were evaluated. RESULTS: Thirty-six (90%) of the examined individuals (mean follow-up age 22.2â¯y; mean follow-up time 13.5â¯y) were affected by CMB. Longer follow-up time and higher craniospinal irradiation doses correlated with higher total lesion count (pâ¯<â¯0.01). Thirteen patients (32.5%) presented with clinical symptoms. Individuals with CMB were more severely disabled than patients without CMB (pâ¯<â¯0.05). CONCLUSIONS: Cerebrovascular sequelae occur frequently after treatment for pediatric brain tumor. In this study, a remarkable part of pediatric brain tumor patients presents with CMB. As a sign of vascular damage, they can cause clinical symptoms and may correspond to neurocognitive decline. Further studies are needed to standardize MRI protocols and to improve quality of long-term follow-up.
