1.
Science
; 213(4510): 913-5, 1981 Aug 21.
Article
in English
| MEDLINE
| ID: mdl-6114560
ABSTRACT
Species of somatostatin of higher molecular weight were present in the nerve terminals (synaptosomes) of ovine stalk median eminences and were released by depolarizing stimuli. One of these species was identified as the biologically active molecule octacosa somatostatin. Octacosa somatostatin appears therefore to be secreted into the hypothalamic-hypophyseal system, supporting the concept of a role for this peptide in regulating pituitary hormone secretion.
Subject(s)
Hypothalamo-Hypophyseal System/metabolism , Median Eminence/metabolism , Somatostatin/metabolism , Animals , Calcimycin/pharmacology , Ionophores/pharmacology , Membrane Potentials , Molecular Weight , Protein Precursors/metabolism , Radioimmunoassay , Secretory Rate/drug effects , Sheep , Synaptosomes/metabolism
2.
J Mol Cell Cardiol
; 6(1): 39-47, 1974 Feb.
Article
in English
| MEDLINE
| ID: mdl-4150251