1.
Res Commun Chem Pathol Pharmacol
; 15(3): 601-7, 1976 Nov.
Article
in English
| MEDLINE
| ID: mdl-1087041
ABSTRACT
Six glycoalkaloids and one aglycone were tested for cardiotonic activities and compared with K-strophanthoside by use of the isolated frog heart. The decreasing order of potency was as follows: K-strophanthoside greater than tomatine greater than alpha-chaconine=alpha-solanine greater than demissine=commersonine greater than beta-chaconine greater than solanidine. Cardiotonic activity was directly related to the number of sugars in the molecule in which the glycoalkaloids had a common aglycone. On the other hand, glycoalkaloids with dissimilar aglycones, but with identical sugars, such as tomatine and demissine, differed significantly with respect to cardiotonic potency. Apparently, therefore, the cardiotonic activity of glycoalkaloids on the frog heart is determined by the nature of the aglycone and the number of sugars and not by the kinds of sugars or their stereochemical configuration.
Subject(s)
Myocardial Contraction/drug effects , Solanaceous Alkaloids/pharmacology , Animals , Electric Stimulation , In Vitro Techniques , Rana pipiens , Stimulation, Chemical , Strophanthins/pharmacology , Structure-Activity Relationship
2.
Biochem Pharmacol
; 24(13-14): 1313-6, 1975 Jul 15.
Article
in English
| MEDLINE
| ID: mdl-1148019
Subject(s)
Microsomes, Liver/enzymology , Nitrosamines/pharmacology , Aniline Hydroxylase/metabolism , Animals , Body Weight/drug effects , Cytochrome P-450 Enzyme System/analysis , Cytochromes/analysis , Dimethylnitrosamine/metabolism , Dimethylnitrosamine/pharmacology , Ethylmorphine-N-Demethylase/metabolism , In Vitro Techniques , Liver/analysis , Male , Microsomes, Liver/analysis , Microsomes, Liver/drug effects , Nitrobenzoates/metabolism , Organ Size/drug effects , Pentobarbital/metabolism , Rats , Ribosomal Proteins/analysis
3.
J Natl Cancer Inst
; 53(5): 1285-8, 1974 Nov.
Article
in English
| MEDLINE
| ID: mdl-4372381
Subject(s)
Aflatoxins/toxicity , Carcinogens , Carcinoma, Hepatocellular/chemically induced , Fatty Acids/pharmacology , Liver Neoplasms/chemically induced , Animals , Aspergillus flavus , Cyclopropanes/analogs & derivatives , Cyclopropanes/pharmacology , Diet , Drug Synergism , Female , Male , Neoplasms, Experimental/chemically induced , Sex Factors , Time Factors , Trout
4.
Toxicol Appl Pharmacol
; 23(4): 680-91, 1972 Dec.
Article
in English
| MEDLINE
| ID: mdl-4630166
Subject(s)
Liver/drug effects , Nitrosamines/toxicity , Photosensitivity Disorders/chemically induced , Administration, Oral , Animals , Chemical and Drug Induced Liver Injury , Liver/pathology , Male , Mice , Microscopy, Electron , Pentobarbital/pharmacology , Sleep/drug effects , Tetrahymena pyriformis/drug effects , Time Factors
5.
J Am Oil Chem Soc
; 48(10): 599-604, 1971 Oct.
Article
in English
| MEDLINE
| ID: mdl-5111844
Subject(s)
Aflatoxins/pharmacology , Aflatoxins/analysis , Aflatoxins/metabolism , Animals , Cattle , Female , Male , Meat/analysis , Milk/drug effects , Organ Size , Poultry , Reproduction/drug effects , Swine , Time Factors
6.
Toxicol Appl Pharmacol
; 19(1): 81-92, 1971 May.
Article
in English
| MEDLINE
| ID: mdl-4105761
Subject(s)
Solanine/pharmacology , Abdomen/abnormalities , Abnormalities, Drug-Induced , Animals , Anophthalmos/chemically induced , Cardiac Complexes, Premature/chemically induced , Central Nervous System/drug effects , Chick Embryo/drug effects , Depression, Chemical , Electrocardiography , Electroencephalography , Guinea Pigs , Heart Ventricles/drug effects , In Vitro Techniques , Male , Mice , Motor Activity/drug effects , Muscle, Smooth/drug effects , Pentobarbital/pharmacology , Rabbits , Rats , Respiration/drug effects , Respiratory Insufficiency/chemically induced , Sleep/drug effects , Solanine/metabolism , Solanine/toxicity , Stimulation, Chemical , Tachycardia/chemically induced , Tritium , Ventricular Function
7.
Toxicol Appl Pharmacol
; 17(1): 244-9, 1970 Jul.
Article
in English
| MEDLINE
| ID: mdl-5456641
Subject(s)
Pyrazines/pharmacology , Animals , Anticonvulsants/pharmacology , Central Nervous System/drug effects , Glucose/metabolism , Hypnotics and Sedatives/pharmacology , Imidazoles/pharmacology , Male , Mice , Pentylenetetrazole , Phenobarbital/pharmacology , Reflex/drug effects , Seizures/chemically induced
8.
Toxicol Appl Pharmacol
; 14(2): 301-7, 1969 Mar.
Article
in English
| MEDLINE
| ID: mdl-5772854
Subject(s)
Imidazoles/toxicity , Animals , Anticonvulsants/pharmacology , Chickens , Chlordiazepoxide/pharmacology , Electroencephalography , Heart Rate/drug effects , Mice , Motor Activity/drug effects , Pentobarbital/pharmacology , Pentylenetetrazole/pharmacology , Phenytoin/pharmacology , Pyrazines/pharmacology , Rabbits , Respiration/drug effects , Respiratory Paralysis , Seizures/chemically induced
9.
Mycopathol Mycol Appl
; 31(3): 327-31, 1967 Apr 28.
Article
in English
| MEDLINE
| ID: mdl-6067722
