Cardiac transplantation in survivors of lymphoma: a multi-institutional survey.

BACKGROUND: Cardiac transplantation has been successfully performed in patients with a history of presumably cured Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL). Though the risk of recurrence is a major concern, the long-term influence of prior cancer and cancer therapy on posttransplant outcome has not been previously investigated. METHODS: Questionnaires were sent to 130 cardiac transplant centers in the United States registered with the United Network for Organ Sharing. Data collected included patient demographics; type, stage, and timing of HD/NHL; treatment for HD/NHL; posttransplant immunosuppressive regimen, rejection history, and outcomes; and Epstein-Barr virus status. RESULTS: Thirty-four cardiac transplant recipients with a previous history of HD (n=16) or NHL (n=18) were identified. HD patients averaged 41+/-15 years of age, with a mean disease-free interval of 15+/-9 years at the time of transplantation. NHL patients averaged 42+/-17 years of age with a mean disease-free interval of 10+/-9 years at the time of transplantation. The mean follow-up for the entire group was 50 months (range, 2 days to 136 months), and mean follow-up for the survivors was 67 months (range, 23-136 months). The 1-, 3-, 5-, 7-, and 10-year actuarial survival estimates for the entire group are 77%, 64%, 64%, 64%, and 50%, respectively. Actuarial survival was lower in HD patients (P=0.04) and in patients who had previously undergone splenectomy (P=0.008). Cox regression analysis identified only prior splenectomy (P=0.02) as an independent risk factor for mortality after cardiac transplantation with an adjusted relative risk of 6.2 (1.7-21.9, 95% confidence intervals). CONCLUSIONS: Although the numbers are small, these data strongly suggest that there is an increased mortality risk for cardiac transplant recipients with prior HD who have undergone splenectomy.

Facoemulsificaçäo: a experiência da conversäo; análise dos primeiros casos / Conversion from extracapsular cataract surgery to phacoemulsification: analysis of 50 consecutives cases

A conversäo da cirurgia de extraçäo extracapsular de catarata para a facoemulsificaçäo é inevitavelmente associada à chamada curva de aprendizado. Analisamos prospectivamente 50 cirurgias consecutivas de catarata feitas por um grupo de cirurgiöes de segmento anterior fazendo a transiçäo para a facoemulsificaçäo. Os parâmetros avaliados nos períodos pré e pós-operatórios foram acuidade visual melhor corrigida, refraçäo, biomicroscopia, tonometria, ceratometria e oftalmoscopia. A acuidade visual corrigida final foi de 20/40 ou melhor, em 42 (84 por cento) olhos operados. Perda de humor vítreo ocorreu em 6 olhos (12 por cento). Esses resultados säo comparáveis aos de outros estudos de transiçäo para a facoemulsificaçäo. Com preparaçäo cuidadosa, seleçäo apropriada dos pacientes, técnica meticulosa e aprendizado supervisionado (mesmo para o cirurgiäo experiente), a curva de aprendizado durante a conversäo de extracapsular para a facoemulsificaçäo pode ser bem manipulada para o bem estar dos pacientes e obtençäo de resultados aceitáveis