1.
Bull Exp Biol Med
; 134(1): 8-11, 2002 Jul.
Article
in English
| MEDLINE
| ID: mdl-12459855
ABSTRACT
The effect of 5-hydroxytryptamine (serotonin) on neuromuscular transmission in frog skeletal muscle was studied using voltage clamp technique. Serotonin produced no effect on end-plate currents during low frequency electrical stimulation of the motor nerve, but increased the amplitude depression of multiquantal currents during high-frequency stimulation similar to motor commands fired by motoneurons. It was shown that the inhibitory effect of serotonin on neuromuscular transmission is determined by slow potential-dependent block of open ionic channels in the postsynaptic membrane accumulating during rhythmic activation of the synapse.
Subject(s)
Muscle, Skeletal/drug effects , Serotonin/pharmacology , Acetylcholine/metabolism , Acetylcholinesterase/pharmacology , Animals , Electrophysiology , Ions , Membrane Potentials , Muscle, Skeletal/metabolism , Neostigmine/pharmacology , Neurons/metabolism , Ranidae , Sciatic Nerve/metabolism , Serotonin/metabolism , Time Factors
2.
Biull Eksp Biol Med
; 126(9): 256-8, 1998 Sep.
Article
in Russian
| MEDLINE
| ID: mdl-9805605
Subject(s)
Bradykinin/pharmacology , Motor Endplate/drug effects , Synapses/drug effects , Acetylcholine/metabolism , Animals , Electric Stimulation , In Vitro Techniques , Membrane Potentials/drug effects , Motor Endplate/physiology , Muscle, Skeletal/drug effects , Muscle, Skeletal/physiology , Periodicity , Rana temporaria , Sciatic Nerve/drug effects , Sciatic Nerve/physiology , Synapses/physiology , Synaptic Transmission/drug effects
3.
Ross Fiziol Zh Im I M Sechenova
; 83(7): 77-84, 1997 Jul.
Article
in Russian
| MEDLINE
| ID: mdl-9487035
