ABSTRACT
The activity of phosphoinositide and adenylate cyclase systems of second messengers in rat brain were investigated under altitude chamber treatment (6000 m x 24 hours). Selective suppression of each messenger system was achieved by pretreatment of rats with either lithium chloride or propranolol for 8 days. Consequences of this treatment and/or hypoxia were evaluated by orientation behavior and physical exercise test. Administration of LiCl caused reduction of phosphoinositide level; hypoxia (6000 m) caused further impairments in the second messenger content. The synergism between phosphoinositide and adenylatcyclase systems was demonstrated.
Subject(s)
Adenylyl Cyclases/metabolism , Hypoxia/metabolism , Phosphatidylinositols/metabolism , Second Messenger Systems/physiology , Adenylyl Cyclase Inhibitors , Adrenergic beta-Antagonists/pharmacology , Altitude , Animals , Brain/enzymology , Brain/metabolism , Hypoxia/enzymology , Lithium/pharmacology , Phosphatidylinositols/antagonists & inhibitors , Propranolol/pharmacology , RatsABSTRACT
Drug treatment of cerebrovascular disorders alone and in combination with UV irradiation of autoblood gave rise to a positive trend in clinical and functional parameters more noticeable in the combined treatment. Also, there was a fall in red cell levels of malonic dialdehyde. A course of speleotherapy given to children with bronchial asthma contributed to normalization of free radical oxidation and reestablishment of molecular structure in red cell membranes.
