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Bioorg Med Chem Lett
; 14(3): 653-6, 2004 Feb 09.
Article
in English
| MEDLINE
| ID: mdl-14741262
ABSTRACT
A total of 20 new phenylenedithiourea derivatives was synthesized by reaction of phenylenediisothiocyanates with aromatic amines as aminobenzoic, aminosalicylic acid and their derivatives. Their chemical structures were confirmed by elemental analysis, IR spectrometry and 1H NMR. The compounds were screened for in vitro antifungal, antibacterial activities and some of them have strong antifungal activities comparable to the activity observed for ketoconazole.