Measurement-based preparation of multimode mechanical states.

Nanomechanical resonators are a key tool for future quantum technologies, such as quantum force sensors and interfaces, and for studies of macroscopic quantum physics. The ability to prepare room temperature nonclassical states is a major outstanding challenge. It has been suggested that this could be achieved using a fast continuous measurement to break the usual symmetry between position and momentum. Here, we demonstrate this symmetry breaking and use it to prepare a thermally squeezed mechanical state. Our experiments take advantage of collective measurements on multiple mechanical modes, which we show can increase the measurement speed and improve state preparation. Theoretically, we show that this result extends to the quantum regime, relaxing the requirements to generate nonclassical states. We predict that multimode conditioning can enable room temperature quantum squeezing with existing technology. Our work paves the way toward room temperature quantum nanomechanical devices and toward their application in quantum technology and fundamental science.

Slow oscillating transcranial direct current stimulation during sleep has a sleep-stabilizing effect in chronic insomnia: a pilot study.

Recent evidence suggests that lack of slow-wave activity may play a fundamental role in the pathogenesis of insomnia. Pharmacological approaches and brain stimulation techniques have recently offered solutions for increasing slow-wave activity during sleep. We used slow (0.75 Hz) oscillatory transcranial direct current stimulation during stage 2 of non-rapid eye movement sleeping insomnia patients for resonating their brain waves to the frequency of sleep slow-wave. Six patients diagnosed with either sleep maintenance or non-restorative sleep insomnia entered the study. After 1 night of adaptation and 1 night of baseline polysomnography, patients randomly received sham or real stimulation on the third and fourth night of the experiment. Our preliminary results show that after termination of stimulations (sham or real), slow oscillatory transcranial direct current stimulation increased the duration of stage 3 of non-rapid eye movement sleep by 33 ± 26 min (P = 0.026), and decreased stage 1 of non-rapid eye movement sleep duration by 22 ± 17.7 min (P = 0.028), compared with sham. Slow oscillatory transcranial direct current stimulation decreased stage 1 of non-rapid eye movement sleep and wake time after sleep-onset durations, together, by 55.4 ± 51 min (P = 0.045). Slow oscillatory transcranial direct current stimulation also increased sleep efficiency by 9 ± 7% (P = 0.026), and probability of transition from stage 2 to stage 3 of non-rapid eye movement sleep by 20 ± 17.8% (P = 0.04). Meanwhile, slow oscillatory transcranial direct current stimulation decreased transitions from stage 2 of non-rapid eye movement sleep to wake by 12 ± 6.7% (P = 0.007). Our preliminary results suggest a sleep-stabilizing role for the intervention, which may mimic the effect of sleep slow-wave-enhancing drugs.