[Various factors of nonspecific resistance in pregnant women with anemia]. / Nekotorye faktory nespetsificheskoi rezistentnosti pri anemii beremennykh.

Eighty-two women whose pregnancy was complicated by anemias of varying severity and twelve healthy pregnant women were examined. Blood plasma immunoglobulins A, G, and M were measured by immunochemical methods, as were the immune complexes of various levels and some parameters of the homeostasis system. The findings evidence a noticeable elevation of the concentrations of all immunoglobulins, of low-disperse immune aggregates in severe anemia of pregnancy, as well as intensive synthesis of immunoglobulin M in the fetus, low level of large immune complexes, and stimulation of some homeostasis components that results in consumption coagulopathy and chronic DIC syndrome. Correlations between some parameters of the blood coagulation and fibrinolysis systems, on the one hand, and humoral immunity characteristics, on the other, may be traced, among these correlations being reverse correlations between IgG level, activated recalcification time, fibrinogen concentration, and activated partial thromboplastin time.

[Peptide endotoxins and disruption of the hemostasis system during a complicated pregnancy]. / Peptidnye éndotoksiny i narushenie sistemy gemostaza pri oslozhnennom techenii beremennosti.

Peptide fractions, affecting the state of the hemostasis system, were isolated from blood plasma of patients with abnormal development of pregnancy. The functional activity of homogeneous peptide preparation was expressed as induction of ADP-dependent thrombocytes aggregation.

[The level of autoantibodies to thrombin in the plasma of healthy subjects detectable using an immunochemical analyzer]. / Soderzhanie autoantitel k trombinu v plazme zdorovykh liudei, vyiavliaemykh immunokhimicheskim analizatorom.

The existence of autoantibodies to the active factors of blood coagulation was confirmed by the usage of immunochemical analyzer. Autoantibodies to thrombin were stated to exist both in IgG and IgM and IgA fractions of immunoglobulins. Dose-effect of thrombin was determined. The greatest binding of autoantibodies by thrombin takes place in antigen of 0.125 mg/ml concentration.