ABSTRACT
The processes of organization and fibrosing were investigated in the tuberculosis-involved and non tuberculosis-involved lung tissue of the lungs and their parts resected in 307 patients with different forms of tuberculosis by histological, histochemical, luminescence microscopic, biochemical, and morphometric studies. When tuberculous lesions develop and begin fibrosing, there was impairment of final formation of collagenous fibers in their inner area due the low proliferative capacity of epithelioid and giant cells, shortage of fibrogenic cells and precipitation on the argyrophilic fibrillary network of tissue degradation products. Etiologically, pathogenetically, and histogenetically, the development of tuberculous lesions gives rise to posttuberculous fibrosis while that of extratuberculosis lesions leads to metatuberculous fibrosis due to the modification and coarsening of preformed connective tissue. The formation of fibrosis is caused by a combination of definite factors: clinicomorphological forms of tuberculosis, long-term history of the disease, the extent of lung tissue decay, old age, the pattern of antituberculous treatment (regular or regular), the extent of the impaired capillary network, the type of arbitrarily fibrogenic cells functioning inside and outside the area of inflammation.
Subject(s)
Pulmonary Fibrosis/pathology , Tuberculosis, Pulmonary/pathology , Granulation Tissue/pathology , Humans , Lung/pathology , Pulmonary Fibrosis/etiology , Tuberculosis, Pulmonary/complications , Tuberculosis, Pulmonary/drug therapyABSTRACT
Tuberculosis morbidity and mortality in the Moldova Republic has deteriorated since 1991. The percentage of advanced and rapidly progressive forms of the disease rose 2-3-fold. Most of the patients are 21-50-year-old unemployed men living in poor financial and social conditions. Advanced and rapidly progressive tuberculosis forms present clinically with multiple symptoms and destructions, high incidence of generalized dissemination and involvement of the brain. Treatment effectiveness depends on feasibility of combined therapy incorporating 4-5 antituberculous drugs. After the treatment, 84.1% of the patients stopped bacterial discharge, closure of the caverns was achieved in 55.3% of the patients.
Subject(s)
Tuberculosis, Pulmonary , Acute Disease , Adult , Antitubercular Agents/therapeutic use , Disease Progression , Humans , Incidence , Male , Middle Aged , Moldova/epidemiology , Retrospective Studies , Survival Rate , Tuberculosis, Pulmonary/diagnosis , Tuberculosis, Pulmonary/drug therapy , Tuberculosis, Pulmonary/epidemiologyABSTRACT
The tests on guinea pigs proved that amniocene (a tissue preparation) has a double action (antiinflammatory and potentiating repair processes in the foci of tuberculous lesions). This action manifests itself depending on the type of tuberculous inflammation and produces an effect upon the involution of experimental tuberculosis.
Subject(s)
Antitubercular Agents/administration & dosage , Cell- and Tissue-Based Therapy , Disease Models, Animal , Tuberculosis, Hepatic/therapy , Tuberculosis, Pulmonary/therapy , Tuberculosis, Splenic/therapy , Animals , Guinea Pigs , Liver/drug effects , Liver/pathology , Lung/drug effects , Lung/pathology , Spleen/drug effects , Spleen/pathology , Tuberculosis, Hepatic/pathology , Tuberculosis, Pulmonary/pathology , Tuberculosis, Splenic/pathologyABSTRACT
A 26 year-old woman first complained at a sparse sputum stained with blood. 18 days later haemorrhagic petechias on the lower limbs skin appeared and rapidly disappeared. The gradually enhancing cough was followed by haemoptysis and bleeding. The death occurred at the 41st day of the disease from persisting lung bleeding. The cause of lung bleeding was Wegener's granulomatosis which was characterized by destructive angiitis, haemic and tissue eosinophilia, lymph node granulomatosis and diffuse glomerulonephritis.
