ABSTRACT
Proinflammatory markers were evaluated in patients with chronic heart failure of ischemic origin and essential hypertension with preserved left-ventricular ejection fraction before and after a 6-month course of simvastatin therapy (20 mg/day). The study was carried out in 125 patients with diastolic dysfunction manifested as impaired relaxation and pseudonormalization. The main group received standard therapy for chronic heart failure and simvastatin, controls received only standard therapy. In addition, the results in the main group were compared in patients with different types of left-ventricular diastolic dysfunction. Simvastatin therapy significantly reduced the levels of C-reactive protein and IL-6.
Subject(s)
Anti-Inflammatory Agents/therapeutic use , Heart Failure/drug therapy , Simvastatin/therapeutic use , Aged , Chronic Disease , Female , Humans , Inflammation Mediators/blood , Male , Middle AgedABSTRACT
During the period encompassing 10 sessions of the quadriceps femoris muscle electromyostimulation in athletes (n=72), the following cardiac parameters changed significantly: QT-interval dispersion and the incidence of supraventricular and ventricular extrasystoles decreased, while the circadian index increased. No significant changes in the temporal- and frequency-domain parameters of the heart rate were observed, although there was a clear trend to normalization of the disturbed sympathovagal balance in the athletes.
Subject(s)
Athletes , Electric Stimulation/methods , Electrophysiologic Techniques, Cardiac/methods , Heart/physiology , Quadriceps Muscle/physiology , Adult , Electrophysiological Phenomena , Electrophysiology , Female , Heart Rate/physiology , Humans , Male , Young AdultABSTRACT
Against the background of 10 procedures of electric stimulation of the quadriceps muscle of the thigh performed in 72 athletes we observed a significant increase in volume parameters of the left-ventricular systolic function and increase in diastolic function in a group of athletes during the recovery period. Significant increase in endothelium-dependent values was noted in both groups during electric myostimulation; it directly correlated with all metric and integral echocardiography parameters in main group.
