Norcolut with immune modulators in the complex treatment for hyperplastic uterine processes.

The results are presented of the treatment of 55 patients for hyperplastic endometrial processes with the preparation norcolut combined with the immune modulators thymalinum and myelopidum. It was found that the application of the suggested schemes of the introduction of the medicines mentioned increase the treatment effectiveness and enlarges its possibilities.

Application of short-wave therapy in complex treatment for endometrial cancer.

The dynamics of the cellular immunity indices have been studied in 81 patients with endometrial cancer, during the period of combined surgery and post-operative gamma-therapy and also during short-wave therapy. The results obtained testify to the immunostimulating and immunomodulating effect of electromagnetic irradiation of short-wave frequency, thus providing rehabilitation of the immune system in endometrial cancer patients and serving as the basis for short-wave therapy, including it in the complex of therapies given to this group of patients.

[Changes in the indices of the immune and protease inhibitor systems in physiological pregnancy]. / Izmenenie pokazatelei immunnoi i proteazno-ingibitornoi sistem pri fiziologicheskoi beremennosti.

Studies of the immune and enzymic homeostasis in 26 healthy nonpregnant women and in 30 healthy pregnant women in the course of pregnancy and on days 2-3 after normal labor have revealed that the T immunity system was liable to changes over the course of pregnancy to a greater measure than the B system. A significant elevation of the neutral proteinase activity and slight fluctuations in acid proteinase activities were seen in pregnant women as against nonpregnant ones. Immunoglobulins A, M, G, circulating immune complexes levels and elastase activity and the total activity of antiproteinases were virtually unchanged in pregnancy.

[Status of the immune system in patients with benign epithelial ovarian tumors after surgical treatment]. / Sostoianie immunnoi sistemy u bol'nykh s dobrokachestvennymi épitelial'nymi opukholiami iaichnikov posle khirurgicheskogo lecheniia.

The cellular and systemic immunity has been evaluated in 203 women 6 months and 1, 2, 3 and 4 years following surgery for benign epithelial ovarian tumors (BEOT). The women were in the age range from 18 to 40 years. Immune and endocrine disorders in the postoperative period and recurrence of BEOT or onset of other reproductive tract diseases indicated that the operative removal of the tumors did not eliminate a cause of the disease. Women with a history of surgery need a follow-up for early detection of reproductive dysfunctions and their correction with hormonal and immunomodulating drugs.

[Age-related changes in the indicators of immunological homeostasis in women with intact menstrual rhythm]. / Vozrastnye izmeneniia pokazatelei immunnogo gomeostaza u zhenshchin s sokhranennym ritmom menstruatsii.

Immune status was evaluated with respect to reproductive capacity in 57 apparently normal female volunteers, aged 27 to 50 years, with intact menstrual pattern. The most valuable immune parameters, and major patterns of their change throughout the cycle, such as periovulatory immunosuppression, were identified for women of reproductive age. Correlations between immune and endocrine parameters as well as age-related changes thereof are discussed.

[Effect of thymalin on the immunological indices and morphofunctional structure of the uterus in guinea pigs with endometrial hyperplasia]. / Vliianie timalina na nekotorye immunologicheskie pokazateli i morfofunktsional'nuiu strukturu matki u morskikh svinok s giperplaziei éndometriia.

The efficiency of usage of the preparations of thymalin in hyperplasia of endometrium has been studied in the experiment on 125 female guinea pigs. Indicated pathology was caused by the introduction of oil solution of synestrol during 19 weeks. It is determined that marked hyperplasia of endometrium is developing as a result of prolonged introduction of synestrol in experimental animals and the decrease of the amount of T- and B-lymphocytes takes place. The use of thymalin results in normalization of indexes of immune system and in partial normalization of morphologic structure of endometrium.

[The effect of norkolut on immune system status in patients with dyshormonal myocardial dystrophy and hyperplastic processes of the uterus]. / Vliianie norkoluta na sostoianie immunnoi sistemy u bol'nykh s disgormonal'ni miokardiodistrofiei i giperplasticheskimi protsessami v matke.

Use of norkolut in 34 patients with dyshormonal myocardiodystrophy per 10 mg from the 16-th through 25-th days of the menstrual cycle for 6 months favoured improvement of clinical, ECG-data, normalization of values of the immune system. Three months after discontinuation of norkolut restoration occurred of T gamma, A-RFC at the I phase of menstrual cycle while the content of B-lymphocytes remains reduced. At the II phase of the menstrual cycle one observed a reduction of the absolute content of T gamma-cells, A-RFC.

[Histological and cytological characteristics of structural changes of the endometrium of guinea pigs in health and in experimental glandular hyperplasia]. / Gistologicheskaia i tsitologicheskaia kharakteristika strukturnykh izmenenii éndometriia morskikh svinok v norme i pri éksperimental'noi zhelezistoi giperplazii.

An experiment on 203 guinea-pigs involved morphometric and cytological evaluation of morphofunctional profile of the endometrium and vaginal epithelium at various stages of the estrous cycle and endometrial glandular hyperplasia development. The results permitted the authors to establish morphometric and cytological criteria of estrogenic saturation of the organism, to reveal features of hyperplasia in paired and unpaired uterine parts in experimental exogenic hyperestrogenism. There appeared a correlation between variations in the cytological indices of the vaginal smear and the severity of endometrial hyperplastic process. The tendencies observed for quantitative indices warrant intravital evaluation of the formation of the experimental glandular endometrial hyperplasia and objective assessment of the test treatments.

[Effect of tilorone on the immunological indices of guinea pigs with synestrol-induced glandular hyperplasia of the endometrium]. / Vliianie tilorona na nekotorye immunologicheskie pokazateli u morskikh svinok s zhelezistoi giperplaziei éndometriia, indutsirovannoi sinéstrolom.

The immune system state was studied before and after administration of tilorone (an immunologic adjuvant) to guinea pigs with synestrol-induced glandular hyperplasia of endometrium. The total amount of T- and B-lymphocytes. T-lymphocytes with receptors to the Fc-fragment of IgM and IgG, the content of immune complexes were determined. Immune and nonimmune adherence of neutrophils was investigated as well. It was established that the total amount of T-lymphocytes decreased and the quantity of T-lymphocytes and immune complexes increased with the development of glandular hyperplasia of the endometrium. The tilorone administration normalized the structure of endometrium and T-lymphocyte immune controlling system.