[Significance of HLA genetic factors in the origin of immunologic insufficiency in chronic bronchitis]. / Znachenie HLA-geneticheskikh faktorov v vozniknovenii immunologicheskoi nedostatochnosti pri khronicheskom bronkhite.

As many as 131 healthy persons (donors) and 83 patients suffering from chronic bronchitis, belonging to the Uzbek nationality were examined. It has been established that there are HLA genetic markers of predisposition and resistance to the development of chronic bronchopulmonary pathology in the population under study. The HLA phenotypic features of patients suffering from chronic bronchitis were reflected in the clinical manifestation of the broncho-obstructive syndrome and at the age of the disease debut. One of the mechanisms of the induction of the bronchopulmonary process in the Uzbek population was revealed by means of simulating the functioning of certain subpopulations of immunocompetent cells.

[Immunogenetic examination of families with consanguineous marriages]. / Immunogeneticheskoe obsledovanie semei s blizkorodstvennymi brakami.

14 Uzbek cousin-marriage families have been immunologically examined. 13 persons have been identified, who are probably homozygous in HLA-D region (the results of the reaction in mixed lymphocyte culture). The members of cousin-marriage families, as compared to healthy Russian donors, had lower proliferative response to phytohemagglutinin and concanavalin A and decreased indexes of concanavalin A-induced suppression and natural killer activity against K562 targets (in children). At the same time natural killer activity in adults, T- and B-lymphocyte content and IgM, IgG and IgA levels are similar to the respective indexes in Russian donors.

[Organization of mammalian genome replication: data on the high rate of DNA replication in replicons of structural heterochromatin]. / Organizatsiia replikatsii genoma mlekopitaiushchikh: dannye o vysokoo skorosti replikatsii DNK v replikonakh strukturnogo geterokhromatina.

By the autoradiography, the increase of the mean rate of replication fork movement in DNA was shown for human skin fibroblasts during S-period induced by reseeding the stationary culture; the portion of high-rate replicons growing parallel to the increase in numbers of cells, in which the constitutive heterochromatin was replicating. Furthermore, the heterogeneity of replicons was investigated in regard to the rate of DNA chain growth in asynchronous cell populations of human and three rodent species (Microtus agrestis, Tscherskia triton, Cricetulus griseus). A positive correlation was found between the portion of replicons, with a relatively high rate of replication (more than 60 micron/h), and the relative amounts of C-heterochromatin in genomes of these species. On the basis of these studies it has been assumed, that the replicons with the high rate of DNA chain growth belong to the constitutive heterochromatin.