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Neurosci Lett ; 466(1): 47-51, 2009 Nov 27.
Article in English | MEDLINE | ID: mdl-19765635

ABSTRACT

This study aimed to evaluate the peripheral administration of growth hormone (GH) on AD-like cognitive deficiency in NBM-lesioned rats induced by ibotenic acid (5 microg/microl, in each side). Forty-eight male Wistar rats (20-24 months old; weighing 330+/-30 g) randomly divided into six groups (n=8). The groups include control group, which were intact rats; n-L+GH group: non-lesioned rats with GH treatment (1mg/kg, 9.00 am, for 10 consecutive days); n-L+Veh group: non-lesioned rats with vehicle treatment; L group: NBM-lesioned rats; L+GH group: NBM-lesioned rats with GH treatment and L+Veh group: NBM-lesioned rats with same volume of vehicle treatment. Peripheral administration of GH in control had no effect on learning and memory, while in L+GH group produced a significant enhancement in spatial learning and memory comparing to L and L+Veh groups. The percent of time spent in goal quarter during probe trial has decreased significantly in L and L+Veh groups compared to n-L groups. While it has increased significantly in L+GH group compared to L and L+Veh groups. No significant difference in percent of time spent was seen between the control and n-L groups. The GH has known as a mediate that effect through IGF-1. As the IGF-1 itself is earlier shown to improve cognitive function it is likely that the observed effect of GH is mediated through release of IGF-1 from peripheral tissue into the circulation for further transport across the BBB. This mechanism may result in the improvement of learning and memory in rats with NBM lesion.


Subject(s)
Alzheimer Disease/drug therapy , Basal Nucleus of Meynert/pathology , Cognition Disorders/drug therapy , Growth Hormone/therapeutic use , Alzheimer Disease/pathology , Alzheimer Disease/psychology , Animals , Cognition Disorders/pathology , Cognition Disorders/psychology , Disease Models, Animal , Growth Hormone/administration & dosage , Injections, Subcutaneous , Learning/drug effects , Male , Maze Learning/drug effects , Memory/drug effects , Rats , Rats, Wistar
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