ABSTRACT
We estimated pollution in Lake Edku and the Mediterranean Sea, El-Maadiya Region, with 3 aromatic amines (1-naphthylamine, 2-naphthylamine and benzidine) in the muscle tissue of fish. There were marked seasonal variations in the aromatic amine levels. We also determined oxidative stress (blood glutathione, and catalase activity) and genotoxic effects (chromosomal aberrations and urinary metabolites) in fishermen from each area. The fishermen suffered from oxidative stress and had high levels of the urinary metabolite sulfanilamide [mean (microg/mg creatinine): Lake Edku 20.7, Mediterranean 14.5, controls 5.3]. Frequencies for total chromosomal aberrations were significantly raised in the peripheral blood lymphocytes of fishermen in both areas [frequency (per 100 metaphases): Mediterranean 67, Lake Edku 45, controls 14].
Subject(s)
Environmental Exposure/analysis , Fisheries , Fishes , Fresh Water/analysis , Water Pollutants, Chemical/analysis , 1-Naphthylamine/adverse effects , 1-Naphthylamine/analysis , 2-Naphthylamine/adverse effects , 2-Naphthylamine/analysis , Adult , Animals , Benzidines/adverse effects , Benzidines/analysis , Case-Control Studies , Catalase/blood , Chromosome Aberrations/statistics & numerical data , DNA Damage/physiology , Egypt/epidemiology , Environmental Exposure/adverse effects , Environmental Monitoring/methods , Epidemiological Monitoring , Fishes/metabolism , Fresh Water/chemistry , Glutathione/blood , Humans , Male , Mediterranean Sea/epidemiology , Oxidative Stress/physiology , Seasons , Water Pollutants, Chemical/adverse effectsABSTRACT
We estimated pollution in Lake Edku and the Mediterranean Sea, El-Maadiya Region, with 3 aromatic amines [1-naphthylamine, 2-naphthylamine and benzidine] in the muscle tissue of fish. There were marked seasonal variations in the aromatic amine levels. We also determined oxidative stress [blood glutathione, and catalase activity] and genotoxic effects [chromosomal aberrations and urinary metabolites] in fishermen from each area. The fishermen suffered from oxidative stress and had high levels of the urinary metabolite sulfanilamide [mean [microg/mg creatinine]: Lake Edku 20.7, Mediterranean 14.5, controls 5.3]. Frequencies for total chromosomal aberrations were significantly raised in the peripheral blood lymphocytes of fishermen in both areas [frequency [per 100 metaphases]: Mediterranean 67, Lake Edku 45, controls 14]
Subject(s)
Water Pollutants , DNA Damage , Mutagens , Fishes , Oxidative Stress , Sulfanilamides , Environmental PollutantsABSTRACT
We describe a newborn Arab male with defects similar to those seen in mice heterozygous for the mutant disorganisation (DS) gene. He had complete absence of the left lower limb including the left pelvic bone, hamartomas arising from the abdominal wall, a small penis, absent left half of the scrotal sac, absent left testicle, anterior displacement of the anus, and multiple vertebral defects. The similarity between the proband's anomalies and those found in affected heterozygotes for DS support the possibility of a human homologue of the DS gene.