[Effectiveness of combined resection and exenteration of the pelvic organs as part of the comprehensive treatment of extensive malignancies of the rectum and female genitals]. / Effektivnost' kombinirovannykh rezektsii i ékzenteratsii organov malogo taza kak étapa kompleksnogo lecheniia rasprostranennykh opukholei priamoi kishki i zhenskikh genitalii.

The results of the surgical treatment of 865 patients with extended malignancies of the rectum and female genitals are presented. Combined resection and exenteration of organs of the small pelvis (both radical and palliative to ensure cytoreduction of tumor) were carried out in 695 cases (palliative surgery for symptoms--170). The number of resections and sphincter-saving operations has increased while the lethality rates have dropped in recent years. Three-year survival after combined radical surgery for rectal cancer was 59.1%; five-year survival--49% (palliation with removal of distant metastases--26.0 and 14.8%; without removal--24.2 and 0%, respectively; palliative surgery for symptoms--2.3 and 0%, respectively). In cases of palliative surgery for cytoreduction of tumor of the female genitals, 3- and 5-year survival after removal of all distant foci was 66.2 and 54.1%; partial cytoreduction--42.2 and 28.8%, and surgery for symptoms--13.8 and 13.8%, respectively. Cytoreduction improved both the chances and efficacy of adjuvant radio- and chemotherapy. It is suggested that surgery be included as a component of complex treatment of malignancies; combined cytoreduction is fully justified even if its effect is merely palliative.

[Clinical evaluation of the role of gastrinemia and tumor tissue sensitivity to gastrin in cancer of the large intestines]. / Klinicheskaia otsenka poli gastrinemii i chuvstvitel'nosti opukholevoi tkani k gastrinu v techenii raka tolstoi kishki.

Tumor sensitivity to gastrin in vitro (52) and blood gastrin (112) were assayed in cases of colorectal cancer before surgery. Hypergastrinemia was detected in almost half the group of patients with large bowel tumors. It was found to aggravate the short-term and end results of treatment. At least half the tumors retained sensitivity to gastrin, with prognosis being favorable. It is suggested that medication be used for hormono-metabolic correction and measures be taken to suppress gastrin secretion.

[Current approaches to radical surgical and combined treatment of rectal cancer]. / Sovremennye podkhody k radikal'nomu khirurgicheskomu i kombinirovannomu lecheniiu raka priamoi kishki.

The article gives an analysis of the 30 years experiences with treatment of more than 3200 patients with rectum cancer at a specialized oncological department. Postoperative lethality was 7.3%. In recent years this figure has been decreased (5.2%). The individual programs of treatment were associated with the degree of growing the tumor through the bowel wall and with the metastatic damage of the regional lymph nodes. These factors show that careful as well as extended and combined operations are justified. The advantages of combined methods of treatment and functionally saving surgical interventions have been revealed.

[Features of blood gastrin in patients with colorectal cancer: possible prognostic significance]. / Osobennosti gastrinemii u bol'nykh kolorektal'nym rakom: vozmozhnoe prognosticheskoe znachenie.

Blood-gastrin levels were assayed in 112 cases of colorectal carcinoma. Elevated concentrations of gastrinemia were identified in the patients as compared with healthy controls, on the basis of averaged data. An inverse correlation between hypergastrinemia incidence and stage was observed. It was matched by a tendency of increased concentration of gastrin in elderly patients. The data on two-year follow-up pointed to an inverse correlation between survival and preoperative level of gastrinemia.