Subject(s)
Duodenal Ulcer/pathology , Gastric Mucosa/pathology , Helicobacter Infections/pathology , Helicobacter pylori/drug effects , Adolescent , Adult , Amoxicillin/administration & dosage , Amoxicillin/therapeutic use , Anti-Bacterial Agents/administration & dosage , Anti-Bacterial Agents/therapeutic use , Anti-Ulcer Agents/administration & dosage , Anti-Ulcer Agents/therapeutic use , Biomarkers/metabolism , Clarithromycin/administration & dosage , Clarithromycin/therapeutic use , Drug Therapy, Combination , Duodenal Ulcer/drug therapy , Duodenal Ulcer/metabolism , Duodenal Ulcer/microbiology , Endoscopy, Digestive System , Female , Gastric Juice/metabolism , Gastric Mucosa/drug effects , Gastric Mucosa/metabolism , Gastric Mucosa/microbiology , Helicobacter Infections/drug therapy , Helicobacter Infections/metabolism , Helicobacter Infections/microbiology , Helicobacter pylori/isolation & purification , Humans , Male , Middle Aged , Omeprazole/administration & dosage , Omeprazole/therapeutic use , Treatment Outcome , Young AdultABSTRACT
UNLABELLED: THE AIM OF INVESTIGATION: To study the effect of schemes second line quadruple therapy on the state of gastric mucosal barrier and NO formation in experimental ulcer. MATERIAL AND METHODS: The study included 60 white male rats weighing 150-190 gr, mixed population. The effect of the standard second-line regimens on the content of the fractions of insoluble glycoproteins, on indicators of NO formation and anaerobic glycolysis in gastric mucosal tissue in experimental ulcer. RESULTS: Quadruple therapy consisting of omeprazole, de-nol, amoxicillin and tetracycline stimulates mechanisms of protective barrier, which has a positive effect on the mechanisms of NO formation. Scheme with omeprazole, de-nol, tetracycline and metronidazole inhibits the synthesis of mucosal barrier, the key mechanisms of NO formation. CONCLUSION: In the plan of correction of mechanisms of cytoprotection in the gastric mucosal tissue quadruple therapy with omeprazole, de ethanol, amoxicillin, and tetracycline is considered to be effective.
Subject(s)
Amoxicillin/pharmacology , Anti-Bacterial Agents/pharmacology , Anti-Ulcer Agents/pharmacology , Gastric Mucosa/metabolism , Omeprazole/pharmacokinetics , Organometallic Compounds/pharmacology , Stomach Ulcer/drug therapy , Tetracycline/pharmacology , Animals , Disease Models, Animal , Drug Therapy, Combination/methods , Gastric Mucosa/pathology , Male , Nitric Oxide/metabolism , Rats , Stomach Ulcer/metabolism , Stomach Ulcer/pathologyABSTRACT
The study examined the interrelation of changes in the protective mucous barrier of the stomach depending on the severity of the ulcer course in a comparative aspect in patients with duodenal ulcer associated with Helicobacter pylori (HP) and without it. It was established that disorders of the mucous barrier in the gastroduodenal zone are caused by a lack of the main component--fucose in patients with associated HP. Changes in the fucose content in the mucous gel of gastric juice depending on the disease severity may be used as a diagnostic criterion. An even and less considerable reduction of the content of insoluble glycoproteins fractions in the mucous gel of gastric juice is characteristic of the patients without associated HP and these changes do not determine the disease severity.
Subject(s)
Duodenal Ulcer/diagnosis , Duodenal Ulcer/microbiology , Gastric Mucosa/chemistry , Glycoproteins/analysis , Helicobacter Infections/complications , Adolescent , Adult , Female , Fucose/analysis , Gastric Juice/chemistry , Humans , Male , Middle Aged , Prognosis , SolubilityABSTRACT
The authors studied the effect of tetracycline therapy (short and long courses) on the indices of chlamydia infection (antigens and antibodies) in Reiter's urogenous disease. The concentration of tetracycline in the blood serum and synovial fluid when administered in a daily dose of 2.0 g (single dose 0.5 g) was determined. It has been established that tetracycline exerts an inhibitory effect on the chlamydia infection not in all the patients suffering from Reiter's disease despite sufficient concentration of the antibiotic in biological fluids (blood serum, synovial fluid). Prolonged courses of tetracycline therapy proved most effective.
Subject(s)
Arthritis, Reactive/drug therapy , Chlamydia Infections/drug therapy , Tetracycline/therapeutic use , Adolescent , Adult , Antibodies, Bacterial/analysis , Antigens, Bacterial/analysis , Arthritis, Reactive/immunology , Chlamydia Infections/immunology , Chlamydia trachomatis/immunology , Humans , Male , Middle AgedABSTRACT
The ultrastructure of the renal medullary interstitial cells was compared with the quantitative estimation of the interstitial space and its proteoglycan content after stimulation (left nephrectomy) and inhibition (indomethacin administration) of the prostaglandin synthesis. Lysosomes were found to play a functional role in the lipid granule depletion and arachidonic acid release. The ratio of lysosomes to lipid granules within the interstitial cells may serve as a criterion of their functional activity in the process of prostaglandin synthesis. Functional state of the rough endoplasmic reticulum of the interstitial cells was indicative of the cells involvement in the production of the mediate intercellular substance.
