ABSTRACT
Background Clinically most apparent symptoms of COVID-19 include fever and cough, which in some patients show a worsening trend but are completely non-apparent in patients who present with an asymptomatic course of the disease. The aim of this study was to identify clinical and biochemical differences among polymerase chain reaction (PCR) positive patients who are either febrile or afebrile. Methods This study was conducted in Rawalpindi Medical University and Allied Hospitals between September and December 2020. All patients who tested positive for reverse transcription polymerase chain reaction (RT-PCR) COVID-19 were included in the study. After evaluation of 146 patients, 100 were selected, and with a response rate of 97%, a total of 97 patients were included in the final analysis. Depending on the presence of fever, the participants were divided into two groups. Both groups were then compared for baselines vitals and laboratory investigations. Data was entered and analyzed in SPSS v23.0 (IBM Inc., Armonk, New York). Results Among the 97 patients, 66 (68%) of the participants were male, and 31 (32%) were females. The mean age of the study participants was 45.23±18.08 years. Fever was present in 39 (40.2%) of the participants. When compared with patients with no fever, the patients with fever had greater severity of disease (p<0.001), higher heart rate (p<0.001), decreased oxygen saturation (p<0.001). Among the laboratory investigations, the fever group had a greater tendency of having deranged alanine aminotransferase (ALT) (70.82±29.23 vs. 32.83±16.22, p=0.010), Lymphocytes (1.56±0.54 vs. 2.12±0.94, p=0.003) and serum total bilirubin (1.06±0.36 vs. 0.55±0.21, p=0.009). Based on multiple regression analysis, the presence of fever is a predictor of derangement in ALT (OR=1.034, CI=1.001-1.068 p=0.025) and total bilirubin (OR=4.38, CI=2.14-6.78, p=0.021). Conclusion Fever may not be present among all patients presenting with COVID-19 infection, but those who have a fever have a greater risk of having deranged liver function tests. Hence, it is important to monitor liver function tests (LFTs) in COVID-19 patients presenting with fever.
ABSTRACT
Aim and objectives To describe the presenting complaints in acute dengue infection, and identify any differences in presenting complaints between primary and secondary dengue infection patients. Material and methods This cross-sectional observational study was conducted at the Department of Infectious Diseases and Medicine, Holy Family Hospital, Rawalpindi, from July 2019 to December 2019 during the Dengue Rawalpindi Epidemic 2019. Presenting complaints of patients who fulfilled the inclusion criteria of the study were recorded on a proforma on their admissions and their informed consent was taken. Of these patients, 70 primary and 70 secondary dengue infection patients were randomly selected for comparison of presenting complaints. The two groups were compared using the chi-square test and a P-value of <0.05 was considered significant. Results Intermittent fever (88.6%), headache (85%), myalgia (87.9%), arthralgia/bone pain (75%), and retro-orbital pain (47.9%) were common in most dengue patients. Hemorrhagic manifestations, such as rash (15%), epistaxis (11.4%), gum bleeding (15%), melena (7.9%), hematemesis (6.4%), hemoptysis (5.7%), and hematuria (6.4%), were less common. Abdominal pain was significantly more common in secondary dengue infections (50% in secondary dengue infections compared to 32.9% in primary dengue infections). Conclusions Fever, headache, myalgia, arthralgia/bone pains, retro-orbital pain as well as rash, epistaxis, gum bleeding, melena, hematemesis, hemoptysis, hematuria, and decreased urine output despite fluid intake are presenting complaints of dengue infection. Patients with abdominal pain in addition to the above presenting complaints are more likely to be cases of the more serious secondary dengue infection.
ABSTRACT
OBJECTIVE: The objective of this case report is to emphasize the importance of considering uncommon conditions like Fahr's disease in the differential diagnosis of seizures and cognitive impairment, especially in patients with a history of thyroidectomy. MATERIAL AND METHODS: A 56-year-old woman who had undergone subtotal thyroidectomy 25 years previously presented with movement disorder and cognitive impairment secondary to hypoparathyroidism. A CT scan of the brain showed pathognomonic bilateral calcification in the basal ganglia, thalamus and cerebellar nuclei. RESULT: The patient was diagnosed with Fahr's disease caused by post-thyroidectomy hypoparathyroidism and successfully managed with oral calcium, carbidopa/levodopa and haloperidol. CONCLUSION: We recommend the routine use of CT scanning in the long-term follow-up of post-thyroidectomy patients. LEARNING POINTS: CT scans of the brain should be routinely carried out as part of long-term follow-up after thyroidectomy.Cognitive impairment and/or seizures should also be investigated using brain imaging.Taking a detailed history is a cornerstone of diagnosis in internal medicine.
