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Nat Prod Commun ; 11(12): 1847-1850, 2016 Dec.
Article in English | MEDLINE | ID: mdl-30508348

ABSTRACT

Eight known secondary metabolites were isolated from the methanolic extract of the whole plant of Astragalus lycius Boiss. They were identified as 5,5'-dihydoxy-3'-methoxy-isoflavone-7-0-ß-D-glucoside (1), genistin (2), sissotrin (3), 5,4'-dimethoxy-isoflavone-7-0-ß-D-glucopyranoside (4), (7S,8R)-5-methoxydehydrodiconiferyl alcohol-4-0-ß-D-glucopyranoside (5), 4-0-lariciresinol-glucoside (6), 2-phenylethyl-ß-D-glucopyranoside (7) and ß-sitosterol-3-O-ß-D-glucopyranoside (8) by spectroscopic methods including (1)H- and (13)C-NMR and HR-MS experiments, and by comparison with literature values. Compounds 1-7 are reported for the first time from Astragalus taxa. All of the compounds were tested for their cytotoxic activities against a number of cancer cell lines. Among them, only 6 exhibited significant activity against human colon carcinoma (HT-29) at 2.69 µM concentration.


Subject(s)
Antineoplastic Agents , Astragalus Plant/metabolism , Phytochemicals , Antineoplastic Agents/analysis , Antineoplastic Agents/metabolism , Antineoplastic Agents/pharmacology , Cell Line , Cell Survival/drug effects , Humans , Phytochemicals/analysis , Phytochemicals/metabolism , Phytochemicals/pharmacology , Secondary Metabolism
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