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Bioorg Med Chem Lett
; 15(15): 3584-7, 2005 Aug 01.
Article
in English
| MEDLINE
| ID: mdl-15967664
ABSTRACT
In a three-step sequence, an array of angularly fused polycyclic heterocycles with coumarin, benzofuran and pyridine rings were synthesized from 4-bromomethylcoumarins and salicylonitrile. All the final compounds were fully characterized and screened for anti-microbial, anti-inflammatory and analgesic activities. Several compounds exhibited promising inflammation inhibiting and anti-microbial properties.