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Bioorg Med Chem ; 15(21): 6830-3, 2007 Nov 01.
Article in English | MEDLINE | ID: mdl-17761420

ABSTRACT

Derivatives of chlorogenic acid or its analogues were synthesized by coupling protected chlorogenic acid or its analogues with p-octyloxyaniline and selected amino acids. Most of the compounds exhibited significant potency against Cryptococcus neoformans and Candida species with low toxicity to brine shrimps. The 4,5-dihydroxyl groups in the quinic acid moiety were necessary for the activity and introduction of a free amino group increased the inhibitory activity against Aspergillus fumigatus.


Subject(s)
Antifungal Agents/chemistry , Antifungal Agents/pharmacology , Aspergillus fumigatus/drug effects , Candida/drug effects , Chlorogenic Acid/analogs & derivatives , Cryptococcus neoformans/drug effects , Antifungal Agents/chemical synthesis
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