[Level of estrogen receptors in breast tumors: role of ethnic factors]. / Soderzhanie retseptorov éstrogenov v opukholiakh molochnoi zhelezy: rol' éthnicheskikh faktorov.

Estrogen receptor levels have been assayed in breast cancer patients. A significant increase in receptor-negative tumors was found in Kazakh menopausal women. The proportion of receptor-positive tumors correlated inversely with tumor progression, irrespective of ethnicity. A significant rise in the incidence of receptor-negative tumors was recorded in Kazakh females with breast cancer stage III.

[Adrenal cortical function, immunological reactivity and the blood serum cholesterol level of esophageal cancer patients]. / Funktsiia kory nadpochechnikov, immunologicheskaia reaktivnost' i uroven' kholesterina syvorotki krovi u bol'nykh rakom pishchevoda.

Functional status of the adrenal cortex was studied in 80 patients (aged 31-70) suffering esophageal cancer (predominantly stage III). Blood serum showed high levels of cortisol and 11-HCS and a decrease in those of 17-HCS and 17-KS. Groups with hypo-, normo- and hypercholesterolemia were formed. Lowered blood-cholesterol levels were more frequent in cancer patients as compared to healthy subjects. Cases under study revealed decreased immunologic vigor. A peak concentration of cortisol was matched by a decrease in E-RFC level and a sharp drop in that of blood serum cholesterol. Combined chemoradiation treatment partially brought glucocorticoid and 17-KS levels to normal but did not affect cell-mediated immunity. Complex immunocorrection and chemoradiation treatment normalized hormonal function and immunologic indexes.

[Level of steroid and tropic pituitary hormones in the blood of patients with breast cancer treated with tamoxifen]. / Uroven' steroidnykh i nekotorykh tropnykh gormonov gipofiza v syvorotke krovi u bol'nykh rakom molochnoi zhelezy pri lechenii tamoksifenom.

A radioimmunologic assay of steroid and tropic hormones levels in blood serum was carried out in 30 breast cancer patients receiving tamoxifen. Long-term treatment with tamoxifen was followed by a significant decrease in blood-estradiol, progesterone, testosterone and prolactin levels whereas FSH, LH and hydrocortisone concentrations remained virtually unchanged.