Subject(s)
Leukemia, Myeloid, Acute/pathology , Nevus, Intradermal/pathology , Nevus, Pigmented/pathology , Skin Neoplasms/pathology , Aged , Diagnosis, Differential , Humans , Immunohistochemistry , Leukemia, Myeloid, Acute/diagnosis , Male , Melanoma/diagnosis , Melanoma/pathology , Nevus, Intradermal/diagnosis , Nevus, Pigmented/diagnosis , Skin Neoplasms/diagnosisABSTRACT
We report a case of a 65-year-old marathon runner who presented with painful plaques, which were worse in cold weather and progressed to ulceration. A punch biopsy revealed vascular endothelial hyperplasia and an appearance consistent with reactive angioendotheliomatosis (RAE), a rare, but benign disorder of the skin. Subsequent investigations resulted in the diagnosis of type I cryoglobulinemia; the lesions resolved completely following treatment of the underlying disorder with lenalidomide.
Subject(s)
Cryoglobulinemia/complications , Hemangioendothelioma/complications , Skin Neoplasms/complications , Aged , Angiogenesis Inhibitors/therapeutic use , Cryoglobulinemia/diagnosis , Hemangioendothelioma/drug therapy , Hemangioendothelioma/pathology , Humans , Lenalidomide , Male , Running , Skin Neoplasms/drug therapy , Skin Neoplasms/pathology , Thalidomide/analogs & derivatives , Thalidomide/therapeutic useABSTRACT
We report a case of lichen striatus in a 37-year-old woman in the third trimester of pregnancy. She presented at 35 weeks of pregnancy with a 6-week history of a pruritic rash on the left side of her abdomen. Examination revealed an erythematous papular eruption arranged in a linear fashion from the umbilicus to the left mid back. Histological examination demonstrated lichenoid perivascular and periadnexal inflammatory infiltrate and the presence of colloid bodies. The eruption resolved prior to delivery with the application of mometasone furoate 0.1% ointment.
