Study of Serum Troponin-I Level in Non-diabetic Hyperglycemic ST Elevation Myocardial Infarction Patients.

The most common cause of premature death in developing countries like Bangladesh is ischaemic heart disease. Cardiac troponin-I (cTnI) is 100 percent tissue specific for the myocardium which has been shown to be a very sensitive and specific biomarker for acute myocardial infarction. As acute myocardial infarction is a stressful condition so, plasma glucose level may also increase in this condition which is stress hyperglycemia and also plasma glucose level may be used for prediction of outcome as it is a cheap and easy available test. The aim of the study is to investigate the impact of the elevation of troponin-I level with plasma glucose level of non-diabetic patients in ST-elevation myocardial infarction. This study which was comparative type of analytical and cross- sectional study carried out in the Department of Physiology, Mymensingh Medical College, Mymensingh, Bangladesh from January 2021 to December 2021. Data was collected from Cardiology Department of Mymensingh Medical College Hospital, Mymensingh. A total number of 70 subjects participated in this study and were grouped as normoglycemic ST elevation myocardial infarction- Control group (Group I) and non-diabetic hyperglycemic ST elevation myocardial infarction- Study group (Group II). The results were calculated and analyzed by using SPSS. Serum troponin-I was measured by Fluorescence Immunoassay (FIA) and plasma glucose estimated by GOD-PAP method. Data were expressed in mean±SD and statistical significance of difference among the groups were calculated by unpaired Student's 't' test. The correlation between different parameter was done by Pearson's correlation coefficient test. In this study, the result suggests that there is significant positive association between serum troponin-I and plasma glucose level in study group (hyperglycemic non-diabetic STEMI) in comparison to control group (normoglycemic STEMI). So, by this study we recommend that routine estimation of these parameters is important for prevention of complications related to acute myocardial infarction.

Admission Plasma Glucose as In-Hospital Outcome Predictor in First Attack of Non-ST Segment Elevation Myocardial Infarction in Non Diabetic Patient.

Coronary artery disease is the leading cause of death and disability globally. The presentation of Non-ST segment elevation myocardial infarction (NSTEMI) is heterogeneous, with different risk levels in terms of death, infarction and recurrence of infarction. Current evidence suggests that plasma glucose level or hyperglycemia is a mediator of worse prognosis of MI. The objective of the study was to correlate on admission plasma glucose level in non-diabetic patient with in-hospital outcome of patients after first attack of NSTEMI. This prospective analytical study was conducted among purposively selected 280 patients with NSTEMI admitted in coronary care unit of Mymensingh Medical College Hospital during the period of June 2016 to May 2017. Data were collected from the informant by face to face interview, clinical examination and investigations using a pretested semi-structured case record form. Data were analyzed by SPSS. Patients were categorized into two groups; Group A: NSTEMI with admission plasma glucose level below 7.8mmol/l, (n=150, Male-110, Female-40). Group B: NSTEMI with admission plasma glucose level ≥7.8mmol/l, (n=130, Male-95, Female-35). Group B (n=130) is divided into two subgroups. Subgroup-I: NSTEMI with Hyperglycemia (7.8-9.3mmol/l), n = 67 (male 44, female 23), Subgroup-II: NSTEMI with Hyperglycemia (≥9.4mmol/l), n = 63 (male 51, female 12). All Patients were non diabetic excluded by HbA1c. The mean left ventricular ejection fraction (LVEF) of Group B, Subgroup-II was significantly less than that of Subgroup-I (p<0.05). Correlation between LVEF levels and on admission plasma glucose level showed statistically significant moderate negative correlation, suggesting that the higher was the level of on admission plasma glucose level; the lower was the LV ejection fraction level in first attack of NSTEMI patients. Correlation coefficient between Troponin-I and plasma glucose level on admission of the study population (r=0.030) suggesting that the higher was the level of admission plasma glucose level the higher was the Troponin-I level in first attack of NSTEMI patients. The more was the plasma glucose level, less was LVEF, more was the heart failure and prolonged hospital stay. The study showed a strong predictor of adverse in-hospital outcome in the various levels of plasma glucose and NSTEMI. There was association between the concentration of the plasma glucose and the extent, severity of disease in the means of mean LVEF, the rate of heart failure and duration of hospital stay. The importance of this finding is even clear that RBS is a standard, valuable diagnostic tool for evaluation of severity and prediction of outcome of patients with NSTEMI.

Patterns of Coronary Artery Anomalous Origin Reviewed by Coronary Angiogram in a Cardiac Center of Bangladesh.

Coronary Angiogarm (CAG) has been used to detect coronary artery anomalies. This cross sectional observational study aimed to assess the prevalence of anomalous origin of the coronary artery in the Bangladeshi patients. The researchers summarized responses of the target patients who underwent coronary angiography (CAG) from August 2010 to March 2011 in United Hospital Ltd., Gulshan, Dhaka, Bangladesh and data of anomalous origin of the coronary artery in Bangladeshi patients were recorded. Eighteen hundred (1800) patients underwent CAG during that period; 66 patients with an anomalous origin of the coronary artery were detected, giving a prevalence of 3.6%. The prevalence of anomalous origin of the coronary artery in Bangladeshi people in this study is 3.6%. CAG can visualize the anomalous origin of the coronary artery and is a useful screening modality.

Physiological and biochemical adverse effects of heavy metals on Brassica oleracea grown in Sanganer area, India.

The paper reveals results of a study carried out in agricultural fields of Sanganer town in India. This town is situated 20 km away from the heart of Jaipur city. In the study area (Amanishah Nalla Sanganer, Jaipur) vegetables are grown in the fields receiving sewerage and textile wastewater. Water, soil and crop (plant samples) were collected from the agricultural fields of Sanganer for analysis. Wastewater (from Amanishsh Nalla) used as irrigation water in agricultural fields of Sanganer town was found to contain 6.127 mg/ L of zinc, 7.116 mg/L of Copper, 5.114 mg/L of Chromium and 4.774 mg/L of lead as the highest amount of respective heavy metals. Soil from agricultural fields was found to contain 11.247 mg/g of zinc, 6.410 mg/g of Copper, 3.514 mg/g of Chromium and 2.619 mg/g of lead. Brassica oleracea (plant material) grown in the Sanganer area was analysed for heavy metal contents. Plant fruit contained 5.730 mg/g of zinc, 7.380 mg/g of Copper, 5.940 mg/g of Chromium and 2.170 mg/g of lead as the highest amount of heavy metals. Use of wasterwater alters the nutritional value of the vegetables grown here and in long run consumption of such vegetables may impose health hazards in human beings, which is a matter of concern.

Effect of textile waste water on tomato plant, Lycopersicon esculentum.

In this study Sanganer town, Jaipur was selected as study area. The plants of Lycopersicon esculentum var. K 21(Tomato) treated with 20 and 30% textile wastewater were analyzed for metal accumulation, growth and biochemical parameters at per, peak and post flowering stages. Findings of the study revealed that chlorophyll content was most severely affected with the increase in metal concentration. Total chlorophyll content showed a reduction of 72.44% while carbohydrate, protein and nitrogen content showed a reduction of 46.83, 71.65 and 71.65% respectively. With the increase in waste water treatment the root and shoot length, root and shoot dry weight and total dry weight were reduced to 50.55, 52.06, 69.93, 72.42, 72.10% respectively. After crop harvesting, the fruit samples of the plants treated with highest concentration of textile waste water contained 2.570 mg g(-1)d.wt. of Zn, 0.800 mg g(-1) d.wt. Cu, 1.520 mg g(-1) d.wt. Cr and 2.010 mg g(-1) d.wt. Pb.

Heavy metal contamination in Pisum sativum var. Azad P-1 grown in Sanganerarea, Rajasthan (India).

Dietary exposure to heavy metals, namely lead (Pb), zinc (Zn) and copper (Cu), has been identified as a risk to human health through the consumption of vegetable crops. This study investigates the source and magnitude of heavy metal contamination in soil and okra growing in Sanganer area. Here the main source of heavy metals is the irrigation water along with some atmospheric deposits. Various plant parts of Pisum sativum var. Azad P-1 were analysed at pre, peak and post flowering stages for Cu, Pb, Zn and Cr content. Average concentrations of Zn, Cu, Cr and Pb in pea fruit were found to be 12.119 +/- 0.605 mg/g, 8.989 +/- 0.449 mg/g, 7.456 +/- 0.387 mg/g and 2.387 +/- 0.133 mg/g respectively.

Organochlorine pesticides in irrigation water of Jaipur City (India).

The present study was carried out to evaluate the pesticide content in irrigation waters used in agricultural fields located in agriculture intensive areas adjoining the Jaipur city (India). Pesticide residues were monitored in irrigation water samples collected from open wells/tube wells located in these areas. Most of the water samples were found to be contaminated. Pesticides--HCH, Endosulphan, Dieldrin--concentrations of tube well/open well irrigation waters in monsoon season ranged from 2.25-12.23 ppb, 3.32-13.18 ppb and 0.081-0.470 ppb respectively. In post-monsoon period the concentrations were in the range of 3.35-15.46ppb for HCH, 4.21-16.08 ppb for Endosulphan and 0.154-1.01 ppb for Dieldrin.

Fluoride contamination status of groundwater in Phulera tehsil of Jaipur district, Rajasthan.

Over the last few decades the water quality is deteriorating in arid and semi-arid regions. Phulera tehsil is facing the problem of groundwater pollution. In the present investigation, determination of fluoride (F) in drinking water was conducted in (200 samples of) 40 villages of Phulera fehsil having fluoride content more than permissible limits (> 1.5 mg l(-1)). After the pilot survey symptoms of skeletal and gut fluorosis have been found in almost every inhabitant. The water samples were alkaline with pH ranging from 7.05 to 10.16. Electrical conductivity (EC) ranged from 157 micromhoScm(-1) to 1018 micromhoS cm(-1). Calcium hardness (Ca-H) ranged from 10 to 127 mg l(-1). Total hardness (TH) varied from 69 to 572 mg l(-1). Chloride varied from 92.00 mg l(-1) to 1422.00 mg l(-1) and fluoride from 1.20 to 18 mg l(-1). The alkalinity of all water samples were found to be more than the permissible limit. The results envisaged that the quality of ground water of Phulera is very poor, and is not suitable for drinking purpose and can only be used after proper treatment.

The toxic effects of sodium fluoride on the reproductive system of male rats.

The present study was undertaken to evaluate the effect of fluoride toxicity on the reproductive system of male rats. Sexually mature male Wistar rats were exposed to 2, 4, and 6 ppm sodium fluoride in their drinking water for 6 months ad libitum. Sperm motility and density in cauda epididymis were assessed. Biochemical and histological analysis were performed in reproductive organs. Fluoride treatment brought about a significant decrease in the weight of testis, epididymis, and ventral prostate. The sperm motility and density were significantly reduced. There was a marked reduction in the number of primary spermatocyte, secondary spermatocyte, and spermatids. The Sertoli cell counts and their cross sectional surface areas were significantly decreased. The Leydig cell nuclear area and the number of mature Leydig cells were also significantly decreased. The protein content of the testis and epididymis were significantly reduced. Fructose in the seminal vesicles and cholesterol in testes were increased significantly. In conclusion, sodium fluoride administrated in drinking water of 2, 4, and 6 ppm concentration for 6 months to male rats adversely affected their fertility and reproductive system.

Effect of textile waste water on the spermatogenesis of male albino rats.

Textile waste water released from dyeing and printing industries situated in Sanganer, Jaipur (India), brought about inhibition of spermatogenesis in male rats. Water analysis showed the presence of heavy metals at more than permissible limits. Oral administration of waste water to the rats at the dose level of 26.6 ml kg(-1) body wt. significantly reduced the weights of testes, epididymides and seminal vesicle. Treated animals showed a notable depression of various stages of spermatogenesis. The production of spermatids was inhibited by 70.8% in waste-water-treated rats. The populations of spermatogonia, preleptotene spermatocytes and secondary spermatocytes were decreased by 67.2, 71.1 and 73.2%, respectively. The total number of Sertoli cells was affected after waste water treatment. Reduced sperm count and motility resulted in treated groups. A significant fall in the content of various biochemical parameters of reproductive tissues was observed after water treatment.

Compensatory hyperparathyroidism following high fluoride ingestion - a clinico - biochemical correlation.

OBJECTIVE: To evaluate the effect of varying ingestion of drinking water containing high fluorides and its effect on serum parathyroid hormone. DESIGN: Cross sectional clinical study. SETTING: S.M.S. Medical College, Jaipur. SUBJECT: 200 children were selected from four areas (50 from each area) consuming water containing 2.4, 4.6, 5.6 and 13.5 mg/l of fluoride. All children were in an age group of 6 to 12 years. METHODS: All children were graded for clinical, radiological and dental fluorosis and biochemical estimations were made for serum calcium, serum and urinary fluoride and serum parathyroid hormone. RESULTS: Serum calcium levels were well within normal range in the patients of all areas but an increase in serum parathyroid levels (S. PTH) was noted. The increased S. PTH was well correlated with increase in fluoride ingestion. The severity of clinical and skeletal fluorosis was observed to increase with increase in S. PTH concentration. CONCLUSIONS: High Fluoride ingestion has a definite relationship with increased parathyroid hormone secretion, which may be responsible for maintaining serum calcium levels and may have a role in toxic manifestations of fluorosis.