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J Nat Prod ; 64(2): 243-5, 2001 Feb.
Article in English | MEDLINE | ID: mdl-11430011

ABSTRACT

Bidentatoside I (1) is a new triterpene saponin bearing an unusual dioxopropionic acid unit, isolated from the roots of Achyranthes bidentata. Structural elucidation was performed mainly by chemical and homo- and heteronuclear 2D NMR techniques. This compound did not show any potentiation of the in vitro cytotoxicity of cisplatin in the HT 29 human colon cancer cell line.


Subject(s)
Antineoplastic Agents/isolation & purification , Magnoliopsida/chemistry , Saponins/isolation & purification , Triterpenes/isolation & purification , Antineoplastic Agents/pharmacology , Colonic Neoplasms/drug therapy , Drug Screening Assays, Antitumor , Humans , Magnetic Resonance Spectroscopy , Models, Chemical , Saponins/pharmacology , Triterpenes/pharmacology , Tumor Cells, Cultured
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