Nanotechnology impacting probiotics and prebiotics: a paradigm shift in nutraceuticals technology.

This is proven for a long that the incorporation of probiotics and prebiotics in diet exhibits beneficial effects on intestinal and intrinsic health. Nevertheless, this may encounter loss of vitality all along the absorption in the gastrointestinal tract, leading to meager intestinal delivery of probiotic active ingredients. In recent times, nanotechnology has been passionately used to escalate the bioavailability of active ingredients. Versatile forms of nanoparticles (NPs) are devised to be used with probiotics/prebiotics/synbiotics or their different combinations. The NPs currently in trend are constituted of distinctive organic compounds like carbohydrates, proteins, fats, or inorganics such as oxides of silver and titanium or magnesium etc. This review critically explicates the emerging relationship of nanotechnology with probiotics and prebiotics for different applications in neutraceuticals. Here in this review, formulations of nanoprobiotics and nanoprebiotics are discussed in detail, which behave as an effective drug delivery system. In addition, these formulations exhibit anti-cancerous, anti-microbial, anti-oxidant and photo-protective properties. Limited availability of scientific research on nanotechnology concerning probiotics and prebiotics implies dynamic research studies on the bioavailability of loaded active ingredients and the effective drug delivery system by including the safety issues of food and the environment.

Association of Quantity and Quality of Protein Intake with Depression and Anxiety Symptoms among Adolescent Boys and Girls (13-15 Years) Studying in Public Schools of Delhi.

Data on prevalence of mental health disorders indicates that 4.5% and 3% of the Indian population is suffering from depression and anxiety respectively. Research suggest that a poor quality diet (lacking in macro and micronutrients) may lead to deficiencies that are associated with depression and anxiety disorders. The present research was designed to study the prevalence & association of depression & anxiety with protein intake among adolescent boys and girls (aged 13-15 y) studying in public schools of Delhi. 546 adolescents participated in this cross-sectional study (selected from public schools in Delhi). For the assessment of depression and anxiety symptoms and dietary micronutrient deficiencies Child Behavior Checklist (CBCL; administered to the parents) and 24 h recall and food frequency questionnaire (administered to the subjects) were used respectively. Adolescent Micronutrient Quality Index (AMQI) was further used to assess the protein quality of the diets. Prevalence of depression and anxiety were 33.5% and 27.47% respectively. Assessment of diets through AMQI revealed that low intake of protein rich foods like milk and legumes was significantly associated with higher mean scores of depression (p<0.001) and anxiety symptoms (p<0.001). In the multivariate analysis for depression and anxiety symptoms, it was observed that males who were not consuming milk for breakfast had higher odds of getting depressed (OR: 0.28; 95%CI: 0.10-0.77; p=0.0177) and anxious (OR: 0.28; 95%CI: 0.10-0.77; p=0.0177) and females had higher odds of getting depressed (OR: NE; 95%CI: NE; p≤0.0177). This study highlights the association of mental health with quality and quantity of protein consumed by adolescents. It will also serve as a strategic tool for mental health prevention and management policies designed for adolescents. It also adds to the growing body of research in the area of nutritional psychiatry.

Nutritional Aspects of Depression in Adolescents - A Systematic Review.

Depression is defined as a cluster of specific symptoms with associated impairment affecting 7.4% of the adolescents globally. As part of the systematic review, around 1000 relevant articles published between January 1978 and December 2017 were identified by systematic online search from 6 electronic databases (PubMed, PsycInfo, Science Direct, MEDLINE, Scopus, and Google Scholar) and overall, 56 relevant studies were included in the current review as per the inclusion criteria. Findings highlight the potential importance of the relationship between healthy dietary patterns or quality and positive mental health throughout life span. Various nutrition and dietary compounds have been suggested to be involved in the onset maintenance and severity of depressive symptoms and disorders. Nutritional compounds might modulate depression associated biomarkers. In this context, several healthy foods such as olive oil, fish, nuts, legumes, dairy products, fruits, and vegetables have been inversely associated with the risk of depression and might also improve symptoms. In contrast western dietary patterns including the consumption of sweetened beverages, fried foods, processed meats, baked products have been shown to be associated with an increased risk of depression in longitudinal studies. Diet and nutrition offer key modifiable targets for the prevention of mental disorders. Evidence is steadily growing for the relation between nutrition deficiencies, diet quality and mental health and for the efficacy and use of nutritional supplements to address deficiencies or as augmentation therapies. We advocate recognition of diet and nutrition as crucial factors in prevention and management of mental disorders.