[The rehabilitation of patients with diabetes mellitus and ischemic heart disease]. / O reabilitatsii bol'nykh sakharnym diabetom i ishemicheskoi bolezn'iu serdtsa.

The results of bicycle ergometry testing were studied in 20 patients with diabetes mellitus of type II without clinical signs of circulatory insufficiency, 21 patients with postinfarction cardiosclerosis with undisturbed carbohydrate tolerance, and in 18 healthy persons. The blood level of glucose in patients with diabetes mellitus was investigated on an empty stomach and 30, 60 and 120 min. after physical exercising. Similar changes of bicycle ergometry results were found in diabetic and CHD patients. In compensation of diabetes in response to graded physical exercise glycemic changes were absent, in decompensation glycemia increased in 30 and 60 min. and returned to the basal level 120 min. after testing. Since the results of bicycle exercises in diabetic (compensated) and CHD patients were the same, the principles of their physical rehabilitation must be identical. In patients with decompensated diabetes mellitus a hyperglycemic reaction to graded physical exercise serves the basis for reduction of motor activity in patients with decompensated diabetes mellitus.

[The role of changes in central and intracardiac hemodynamics in lowering the physical work capacity of patients with ischemic heart disease and diabetes mellitus]. / Rol' izmenenii tsentral'noi i vnutriserdechnoi gemodinamiki v snizhenii fizicheskoi rabotosposobnosti u bol'nykh ishemicheskoi bolezn'iu serdtsa i sakharnym diabetom.

The data of bicycle ergometry test and echocardiography were studied and compared in patients with postinfarction cardiosclerosis and type II diabetes mellitus without the clinical signs of heart failure. The patients showed the decreased work fitness and the identity of cardiovascular responses to graded exercise, pointing to the common character of the pathogenesis of these diseases. Both groups of the patients manifested the hyperkinetic type of the central hemodynamics as well as the lowering of the rate of diastolic relaxation and the rise of the end diastolic volume of the left ventricle. The intracardiac hemodynamics of coronary heart disease was characterized, in addition, by the reduction of myocardial contractility of the left ventricle due to focal injuries to the myocardial structures, which are more pronounced than in diabetes mellitus.

[Disorders of the antithrombogenic properties of the vascular wall in patients with ischemic heart disease and their restitution using a complex of pharmaceutical preparations]. / Narushenie antitrombogennykh svoistv stenki sosudov u bol'nykh ishemicheskoi bolezn'iu serdtsa i vosstanovlenie ikh s pomoshch'iu kompleksa farmakologicheskikh preparatov.

Hemostatic studies were carried out in 98 patients with various types of coronary disease and 31 normal subjects, both at relative rest and during the cuff test. High platelet activity in combination with reduced blood anticoagulation and fibrinolytic activity were demonstrated. The cuff test showed reduced antithrombogenic (antiaggregation, anticoagulation, fibrinolytic) properties in the vascular wall. Combined medication has been developed to repair antithrombogenic activity of the vascular wall.

[Functional status of the myocardium in thyrotoxicosis]. / Funktsional'noe sostoianie miokarda pri tireotoksikoze.

Twenty-two patients with thyrotoxicosis, showing no clinical signs of heart failure were examined electro- and echocardiographically. Bicycle ergometry was also used in 13 of those. Central and intracardiac hemodynamics were assessed at rest, as was cardiovascular response to exercise. The results were compared to similar parameters in 18 normal subjects. Echocardiography demonstrated hyperkinetic circulation and normal myocardial contractility in the resting patients. Bicycle ergometry showed considerably limited working capacity in those patients. Limited chronotropic and inotropic reserve of the heart in the presence of increased left-ventricular operation at rest may be pathogenetically involved in reduced stress tolerance, seen in patients with thyrotoxicosis.