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1.
Article in Russian | MEDLINE | ID: mdl-37655414

ABSTRACT

OBJECTIVE: To study the efficacy and safety of Cytoflavin in combination with thrombolytic therapy. MATERIAL AND METHODS: At the first preclinical stage, the effect of Cytoflavin, solution for intravenous administration, on the fibrinolytic activity of alteplase (Actilyse) was studied in vitro. At the second, clinical stage, the safety and efficacy of Cytoflavin treatment, initiated within in the first 24 hours from the stroke onset and continued for 10 days, was evaluated in patients with acute stroke who received reperfusion therapy. At the clinical stage of the study, 200 patients were examined: 100 subjects of the main group who received reperfusion therapy in combination with Cytoflavin; 100 control subjects who received reperfusion therapy in combination with other drugs from the neuroprotective group as part of routine clinical practice. RESULTS: The preclinical study has demonstrated that alteplase in the studied concentrations debulks the mass of a thrombus by 2131%. There were no statistically significant differences in the reduction of thrombus weight with addition of Cytoflavin at various concentrations combined with alteplase to the incubation medium. The addition of Cytoflavin to the incubation medium with alteplase had no effect on the concentration of D-dimer in the rat's plasma. In the clinical study, there were no statistically significant differences in the frequencies of intracranial hemorrhages of various types between the study groups. In the multivariable analysis, significant predictors of intracranial hemorrhage were baseline NIHSS score, systolic blood pressure, history of diabetes and anticoagulant use, baseline CT ASPECTS score, but not the treatment group. CONCLUSION: The use of Cytoflavin in combination with thrombolytic therapy is safe. Up-to-date treatment of stroke which includes timely reperfusion and neurometabolic support of recovery leads to the rapid manifest regression of the neurological deficit and to the improvement in functioning and activity of patients with cerebral infarction.


Subject(s)
Ischemic Stroke , Stroke , Animals , Rats , Tissue Plasminogen Activator , Stroke/drug therapy , Intracranial Hemorrhages , Reperfusion
2.
Article in Russian | MEDLINE | ID: mdl-32790976

ABSTRACT

OBJECTIVE: Based on a retrospective analysis, to evaluate technical results and functional outcomes at discharge after endovascular thrombectomy (EVT) in anterior circulation out of 6-hours «therapeutic window¼ in patients with stroke. MATERIAL AND METHODS: The retrospective analysis of EVT in 594 acute stroke patients (303 male, 291 female, median age 69 years) with the anterior circulation large vessel occlusion was performed. EVT was carried out before 6 hrs in 550, later in 44 patients. Time to artery puncture was defined as a cut point. Patients were included in the study if they met the criterion for 0-6 hours «therapeutic window¼. RESULTS: No significant differences in functional outcomes at discharge assessed with the Rankin scale (mRs 0-2 29.8% and 20.5% p<0.19; mRs 3-5 38.7% and 38.6% p<0.99; mRs 6 31.5% and 40.9% p<0.2) and the rates of intracranial haemorrhage, haemorrhagic transformation and symptomatic haemorrhagic transformation (4% and 0% p<0.17; 20.9% and 29.5% p<0.49; 10.1% and 11.4% p<0.78) were observed in patients exposed to EVT before 6 hrs and later. CONCLUSION: EVT in anterior circulation stroke over 6 hrs «therapeutic window¼ based on the criterion for 0-6 hrs provides comparable functional outcomes at discharge without the increase in the frequency of intracranial haemorrhages, haemorrhagic and symptomatic haemorrhagic transformations.


Subject(s)
Brain Ischemia , Endovascular Procedures , Stroke , Aged , Cerebrovascular Circulation , Female , Humans , Male , Retrospective Studies , Russia , Thrombectomy , Treatment Outcome
3.
Zh Nevrol Psikhiatr Im S S Korsakova ; 118(12. Vyp. 2): 54-63, 2018.
Article in Russian | MEDLINE | ID: mdl-30830118

ABSTRACT

AIM: To assess technical results and close functional outcomes of acute ischemic stroke (AIS) in patients treated with endovascular thrombecomy (ET) in regional vascular centers (RVC) of St-Petersburg. MATERIAL AND METHODS: Retrospective analysis of 183 patients with AIS, including 143 patients with AIS due to a large intracranial vessel occlusion in anterior (AC) and 25 patients in posterior cerebral (PC) circulation, 15 with isolated extracranial carotid occlusion treated in 6 RVC in 2017 was performed. All patients underwent ET. RESULTS AND CONCLUSION: Effective reperfusion (mTICI 2b-3) was achieved in 71.5% (71.3% AC, 72% PC). On discharge, 35,7% patients had good (mRs 0-2) functional outcome (37.1% AC, 28% PC). The incidence of symptomatic intracranial hemorrhage (according to ECASS II criteria) was 10.7% (9.1% AC, 20% PC), the mortality was 29.2% (22.4% AC, 68% PC).). The results of our study show the possibility of effective and safe application of ET in patients with AIS in the anterior and posterior cerebral circulation in regional vascular centers of St.-Petersburg.


Subject(s)
Brain Ischemia , Endovascular Procedures , Stroke , Thrombectomy , Brain Ischemia/therapy , Humans , Retrospective Studies , Stroke/therapy , Treatment Outcome
4.
Zh Nevrol Psikhiatr Im S S Korsakova ; 117(8. Vyp. 2): 13-19, 2017.
Article in Russian | MEDLINE | ID: mdl-28980576

ABSTRACT

AIM: To find clinical criteria applied in the first hours of disease for the identification of severe ischemic stroke caused by an occlusion of proximal major arteries. MATERIAL AND METHODS: The authors have analyzed 133 medical histories of patients with the diagnosis of acute cerebral blood circulation disorder admitted in the first 6 h from onset. All patients underwent CT-angiography or digital subtraction angiography. Occlusion of the inner carotid artery, occlusion of M1-segment of the middle cerebral artery and occlusion of a major artery were considered as proximal occlusion of major cerebral arteries. Neurological status was assessed by the signs of proximal arterial occlusion (PAO). RESULTS AND CONCLUSION: Checking of 5 PAO symptoms allows the prediction of occlusion location in approximately 80% of cases. Presence of ≥3 out of 5 symptoms is characterized by 70% sensitivity and 90% specificity with regard to the occlusion of the inner carotid artery, M1-segment of the middle cerebral artery and/or a major artery. Predictive value of this model should be verified in a prospective study.


Subject(s)
Brain Ischemia , Infarction, Middle Cerebral Artery , Stroke , Brain Ischemia/diagnostic imaging , Brain Ischemia/etiology , Cerebral Angiography , Cerebral Arteries , Humans , Infarction, Middle Cerebral Artery/complications , Infarction, Middle Cerebral Artery/diagnostic imaging , Prospective Studies , Stroke/diagnostic imaging , Stroke/etiology , Tomography, X-Ray Computed
5.
Klin Lab Diagn ; 60(10): 12-6, 2015 Oct.
Article in Russian | MEDLINE | ID: mdl-26841665

ABSTRACT

The laboratory biomarkers can effect on choice of tactics of treatment in patients with atherosclerotic stenosis ofcarotids and high risk of stroke. However, nowadays there is no established laboratory criteria of significant atherosclerotic affection of internal carotid. The purpose of study was to investigate informativeness of biomarkers of atherosclerosis in clinical molecuIar panel of expertise system of determining risk of stroke in patients with significant stenosis of carotid. The study included patients with 50-90% atherosclerotic stenosis of internal carotid in acute period of atherothrombotic stroke or transitory ischemic attack (group 1), patients with stable 50-90% atherosclerotic stenosis of inner carotid having no vascular events during 30 days before engaging into study (group II) and group of healthy volunteers without atherosclerosis of inner carotid. The examination of patients included anamnesis collection, evaluation of neurological status, analysis of serum level of biomarkers of atherosclerosis (lipoprotein-associatedphospholipase A2 (LP-PL A2), serum protein A associated with pregnancy (PA PP-A), lipoprotein (a) (LP(a)), asymmetric dimethylarginine (ADMA), C-reactive protein detected by highly sensitive technique (hsCRP) and lipid spectrum of blood) using enzyme-linked immunosorbent assay, duplex ultrasound scanning of brachiocephalic arteries. The stroke risk factors of other etiology were chosen as exclusion criteria except atherothrombotic one. The Mann-Whitney and Kruskal-Wallis tests were applied to establish group differences. The Data Mining techniques were applied to establish patterns of analyzing sample. Out of 356 examined patients, 30 patients of group 1, 51 patients of group II and 16 healthy volunteers were included in the study. All patients were comparable by gender and age (50-80 years). The serum level of hsCRP and ADMA in the group of patients of acutest period of ischemic stroke was significantly higher than in groups of patients with stable stenosis and healthy volunteers (p < 0.05). The comparison between three groups established no statistically significant differences in serum concentration of PAPP-A, LP-PL A2 and LP(a). The ADMA, hsCRP and PAPP-A can be recommended for including into clinical molecular panel for personalized diagnostic of causes of stroke along with clinical anamnestic data. The serum level of ADMA and hsCRP significantly increases in acute period of atherothrombotic stroke. The analysis of levels of ADMA, hsCR and PPAPP-A interpreted with regard to clinical anamnestic data can be proposed for enhancing quality of diagnostic of causes of stroke.


Subject(s)
Atherosclerosis/blood , Carotid Stenosis/blood , Stroke/blood , Aged , Aged, 80 and over , Arginine/analogs & derivatives , Arginine/blood , Biomarkers/blood , C-Reactive Protein/metabolism , Case-Control Studies , Female , Humans , Male , Middle Aged , Phospholipases A2/blood , Pregnancy-Associated Plasma Protein-A/metabolism
6.
Adv Gerontol ; 27(2): 366-75, 2014.
Article in Russian | MEDLINE | ID: mdl-25306673

ABSTRACT

The article presents the results of prospective longitudinal study. The aim of the study was to investigate influence of complex therapy with chondroitin sulfate on pain and functional disorders in elderly patients with knee osteoarthritis. The study shows sufficient decreasing of pain, stiffness and functional disorders with complex therapy with chondroitin sulfate in comparison with nonsteroidal anti-inflammatory drugs (NSAID) by the second month of therapy with stable effect the next 2 months. All patients decrease their NSAID intake by the end of the study. Satisfaction of complex therapy was high according to patient's and physician's opinion.


Subject(s)
Chondroitin Sulfates/administration & dosage , Osteoarthritis , Age of Onset , Aged , Anti-Inflammatory Agents, Non-Steroidal/administration & dosage , Arthralgia/diagnosis , Arthralgia/physiopathology , Arthralgia/therapy , Combined Modality Therapy , Drug Monitoring , Female , Humans , Injections, Intramuscular , Male , Middle Aged , Osteoarthritis/diagnosis , Osteoarthritis/epidemiology , Osteoarthritis/physiopathology , Osteoarthritis/therapy , Pain Measurement/methods , Patient Education as Topic , Range of Motion, Articular , Risk Factors , Self Care/methods , Severity of Illness Index , Treatment Outcome
7.
Arkh Patol ; 74(1): 7-11, 2012.
Article in Russian | MEDLINE | ID: mdl-22712296

ABSTRACT

13 cases of uterine carcinosarcomas have been studied by molecular-genetic method. The impairment of some genes (K-RAS gene in the first exon, TP53 in the 5th-9th exons, PTEN in the 5th and 8th exons) has been found out. The loss of heterozygosity of TP53 gene in epithelium and mesenchyme of the uterus has been detected. According to the estimation of impairment the studied tumors was divided into monoclonal and biclonal ones. This stratification could be use as prognostic criteria of uterine carcinosarcomas clinical presentation.


Subject(s)
Carcinosarcoma/genetics , Carcinosarcoma/pathology , PTEN Phosphohydrolase/genetics , Proto-Oncogene Proteins p21(ras)/genetics , Tumor Suppressor Protein p53/genetics , Uterine Neoplasms/genetics , Uterine Neoplasms/pathology , Carcinosarcoma/metabolism , Exons , Female , Humans , Loss of Heterozygosity , PTEN Phosphohydrolase/metabolism , Proto-Oncogene Proteins p21(ras)/metabolism , Retrospective Studies , Tumor Suppressor Protein p53/metabolism , Uterine Neoplasms/metabolism
8.
Vopr Onkol ; 57(2): 204-12, 2011.
Article in Russian | MEDLINE | ID: mdl-21809666

ABSTRACT

Clinico-morphological and immunohistochemical examinations were carried out in 46 patients with carcinocarcinoma of the corpus uteri to evaluate p53, PTEN and cyclooxygenase-2 (COX-2) expression in mesenchymal and epithelial cells of tumor. p53 expression in the epithelium and that of COX-2 in both compartments appeared to be unfavorable prognosticators of survival while that of PTEN is a lesser one in significance.


Subject(s)
Biomarkers, Tumor/analysis , Carcinosarcoma/chemistry , Carcinosarcoma/pathology , Cyclooxygenase 2/analysis , PTEN Phosphohydrolase/analysis , Tumor Suppressor Protein p53/analysis , Uterine Neoplasms/chemistry , Uterine Neoplasms/pathology , Adult , Aged , Carcinosarcoma/mortality , Female , Gene Expression Regulation, Neoplastic , Humans , Immunohistochemistry , Middle Aged , Predictive Value of Tests , Prognosis , Survival Analysis , Uterine Neoplasms/mortality
9.
Bull Exp Biol Med ; 151(3): 363-5, 2011 Jul.
Article in English, Russian | MEDLINE | ID: mdl-22451888

ABSTRACT

Outbred female SHR mice (n=200) were divided at random into 4 groups, 50 per group. Benz(a)pyrene solution in acetone was applied onto a skin site on the back during 26 weeks. In parallel, the animals received melatonin, metformin, or both. Melatonin, metformin, and their combination promoted significant reduction of the number and size of skin tumors. In mice receiving no therapy, benz(a)pyrene applications increased the concentrations of malonic dialdehyde in the serum and skin tumor tissue in comparison with the concentrations in the sera and skin of intact mice. Melatonin, metformin, and their combination normalized LPO level.


Subject(s)
Cell Transformation, Neoplastic/drug effects , Lipid Peroxidation/drug effects , Melatonin/pharmacology , Metformin/pharmacology , Skin Neoplasms/chemically induced , Skin Neoplasms/prevention & control , Animals , Antioxidants/pharmacology , Benzo(a)pyrene , Cell Transformation, Neoplastic/metabolism , Female , Malondialdehyde/blood , Mice , Reactive Oxygen Species/metabolism , Skin/pathology , Skin Neoplasms/pathology
10.
Adv Gerontol ; 22(2): 316-21, 2009.
Article in Russian | MEDLINE | ID: mdl-19947395

ABSTRACT

Arterial hypertension contributes essentially into development of chronic heart failure and chronic ischemia of the brain, which results in social dependence of geriatric patients. One of the important factors in the development of arterial hypertension is the state of lipids peroxidation. Misbalance among the products of lipids peroxidation and components of antioxidation defense system revealed in cardiovascular diseases (mainly in arterial hypertension and heart failure) promotes progress of these diseases and premature aging of an organism. The therapy aimed at normalization of the oxidative profile of the patients with arterial hypertension should include prolonged beta-blockers, ACE inhibitors, calcium antagonists, statines and polyvitamin complexes with vitamins A and E.


Subject(s)
Aging/metabolism , Antioxidants/metabolism , Hypertension/metabolism , Lipid Metabolism , Lipid Peroxidation , Aged , Biomarkers/metabolism , Case-Control Studies , Female , Homeostasis/physiology , Humans , Hypertension/enzymology , Male , Malondialdehyde/metabolism , Middle Aged , Oxidation-Reduction , Severity of Illness Index , Sulfhydryl Compounds/metabolism
11.
Vopr Onkol ; 55(6): 751-6, 2009.
Article in Russian | MEDLINE | ID: mdl-20210020

ABSTRACT

Results of clinico-morphological and immunohistochemical studies of 44 cases of carcinosarcoma of the uterus are presented in an attempt to provide pathogenetic rationale for prognosticators of the disease. Immunohistochemical reactions were used to evaluate the expression of genes and mediators p53 and PTEN and cyclooxigenase (COX-2) in cells of mesenchyme and epithelium of tumor to gauge the influence of either component on its biological behavior. All patients were divided into two groups depending on whether they revealed expression of p53, PTEN and cyclooxigenase or not. The end results--overall survival and complete remission duration--were compared in both groups. No dominance of either component of carcinosarcoma was established.


Subject(s)
Biomarkers, Tumor/analysis , Carcinosarcoma/chemistry , Uterine Neoplasms/chemistry , Adolescent , Adult , Aged , Carcinosarcoma/mortality , Carcinosarcoma/pathology , Cyclooxygenase 2/analysis , Disease-Free Survival , Female , Humans , Immunohistochemistry , Middle Aged , PTEN Phosphohydrolase/analysis , Survival Analysis , Tumor Suppressor Protein p53/analysis , Uterine Neoplasms/mortality , Uterine Neoplasms/pathology , Young Adult
13.
Vestn Ross Akad Med Nauk ; (6): 5-8, 2000.
Article in Russian | MEDLINE | ID: mdl-10943151

ABSTRACT

The paper covers the problems of diagnosis of germinogenic ovarian tumors in girls, which make up as high as 80% of all malignant ovarian tumors. For timely diagnosis, it is necessary to take into account clinical data, the levels of tumor markers (alpha-fetoprotein, chorionic gonadotropin) and ultrasound findings. This all is rather sufficient to verify the diagnosis of ovarian tumor lesions. Other additional studies are aimed at establishing where the process extends.


Subject(s)
Germinoma/diagnosis , Ovarian Neoplasms/diagnosis , Adolescent , Angiography , Biomarkers, Tumor/blood , Child , Chorionic Gonadotropin/blood , Colonoscopy , Diagnosis, Differential , Female , Germinoma/blood , Humans , Ovarian Neoplasms/blood , Tomography, X-Ray Computed , Ultrasonography , Urography , alpha-Fetoproteins/metabolism
15.
Vopr Onkol ; 31(6): 22-5, 1985.
Article in Russian | MEDLINE | ID: mdl-4024545

ABSTRACT

Out of 24 patients with brain tumors, 22 proved to be resistant to inhibition by dexamethasone. There were no significant differences in the sensitivity to dexamethasone in three study groups established on the basis of the tumor site-to-diencephalic structures distance. A relatively higher frequency of disturbances in dexamethasone inhibition in patients with brain tumors suggests grave disorders induced in glucocorticoid secretion regulation by chronic stress.


Subject(s)
Brain Neoplasms/physiopathology , Dexamethasone/antagonists & inhibitors , Adult , Aged , Craniopharyngioma/physiopathology , Drug Resistance , Female , Humans , Hypothalamo-Hypophyseal System/drug effects , Male , Meningeal Neoplasms/physiopathology , Meningioma/physiopathology , Middle Aged , Neuroma, Acoustic/physiopathology , Pituitary Neoplasms/physiopathology , Pituitary-Adrenal System/drug effects
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