Subject(s)
Immunization/methods , Influenza Vaccines/immunology , Animals , BCG Vaccine/administration & dosage , BCG Vaccine/immunology , Bacterial Vaccines/administration & dosage , Bacterial Vaccines/immunology , Diphtheria Toxoid/administration & dosage , Diphtheria Toxoid/immunology , Drug Evaluation, Preclinical , Guinea Pigs , Humans , Immunoglobulins/administration & dosage , Immunoglobulins/immunology , Influenza Vaccines/administration & dosage , Mice , Neisseria meningitidis/immunology , Rabbits , Typhoid-Paratyphoid Vaccines/administration & dosage , Typhoid-Paratyphoid Vaccines/immunology , Vaccines, Combined/administration & dosage , Vaccines, Combined/immunology , Vaccines, Inactivated/administration & dosage , Vaccines, Inactivated/immunologyABSTRACT
A safe, moderately reactogenic and immunologically effective scheme of complex (combined) immunization against meningitis A, diphtheria, typhoid fever, viral hepatitis A and influenza has been developed as the result of experimental and clinico-immunological studies. Depending on the epidemiological situation, the newly developed scheme can be used in two variants. According to the first variant of this scheme, the following preparations are injected subcutaneously into three different sites: a mixture of group A meningococcal vaccine and diphtheria toxoid, typhoid vaccine and influenza vaccine. The second variant of the scheme differs from its first variant in using intramuscular injection of normal human immunoglobulin instead of injection of influenza vaccine. Moreover, in practical realization these variants may be altered by excluding vaccines, unnecessary under present conditions. The newly developed scheme of vaccinal prophylaxis is recommended for practical use.