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The Influence of Water-Soluble Polysaccharides of Crataegus sanguinea Pall. on Nitric Oxide Production by Macrophages.
Ligacheva, A A; Sherstoboev, E Yu; Danilets, M G; Trofimova, E S; Krivoshchekov, S V; Khasanova, S R; Kudashkina, N V; Gur'ev, A M; Belousov, M V.
Bull Exp Biol Med ; 172(2): 151-154, 2021 Dec.
Article in English | MEDLINE | ID: mdl-34853963

ABSTRACT

The in vitro addition of water-soluble polysaccharides isolated from the leaves of Crataegus sanguinea Pall. to culture of mouse peritoneal macrophages induced classical activation of antigen-presenting cells by increasing NO synthase activity and reducing arginase expression.


Subject(s)
Crataegus/chemistry , Macrophages, Peritoneal/drug effects , Nitric Oxide/metabolism , Polysaccharides/pharmacology , Animals , Arginase/drug effects , Arginase/metabolism , Cells, Cultured , Female , Macrophages, Peritoneal/enzymology , Macrophages, Peritoneal/metabolism , Mice , Mice, Inbred C57BL , Plant Extracts/chemistry , Plant Extracts/pharmacology , Plant Leaves/chemistry , Polysaccharides/isolation & purification , Solubility , Water/chemistry
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