ABSTRACT
Whether renal transplant recipients with anti-HCV antibodies positivity and normal liver function tests within the first year after transplantation have different morbidity and mortality and graft failure compared to anti-HCV-negative recipients remains controversial. In this retrospective study, on 411 renal transplant recipients, we analyzed grafts morbidity, survival, and liver function tests over a period of 8 years. Patients were stratified according to their anti-HCV antibody status 1 year after transplantation into anti-HCV-positive and HCV-negative patients. The presence of normal liver function tests was mandatory at inclusion. All patients received the same immunosuppressive protocol consisting of cyclosporine A, mycophenolate mofetil and steroids. One year after transplantation, 137 patients were anti-HCV negative (33 %) while the rest 274 (67 %) were positive. At 5 years of follow-up, the study population consisted of 205 patients (71 patients, 35 % with anti-HCV negativity, and 134, 65 % with positivity). At the end of the study, only 144 patients were followed up (43 patients, 30 % with negative anti-HCV and 101 patients, 70 %, with positivity). We found that graft survival was not different between both groups. Moreover, serum creatinine showed a trend to be lower in HCV-positive patients compared to negative group although difference was not statistically significant. The number of graft loss was not different between both groups. Moreover, there was no difference between both groups as regards prevalence of acute rejection, diabetes mellitus, hypertension, CMV disease and proteinuria. We can conclude that anti-HCV positivity for 8 years in patients with normal liver function tests at 1 year does not impact graft morbidity and patient survival.
Subject(s)
Antibodies, Viral/blood , Graft Survival , Hepacivirus/immunology , Hepatitis C, Chronic/blood , Kidney/physiology , Adolescent , Adult , Creatinine/blood , Female , Follow-Up Studies , Genotype , Hepacivirus/genetics , Hepatitis C, Chronic/complications , Humans , Kidney Transplantation , Male , Middle Aged , Retrospective Studies , Young AdultABSTRACT
The effect of schistosomiasis on quality of life (QOL) and productivity of workers was examined. In a textile factory in Alexandria, Egypt, personal, occupational and sociodemographic data were collected from 172 workers with schistosomiasis and 172 workers without schistosomiasis. Several indicators of productivity and the World Health Organization QOL brief were used to determine the impact of schistosomiasis. The disease affected the general, physical and independence, psychological and spiritual, and social domains of QOL. Although the productivity score of workers with schistosomiasis did not differ significantly from the control group, they had significantly lower additional hours of work and lower total incentives/month. A significant relationship was found between severity of schistosomiasis and QOL domains and productivity indicators.
Subject(s)
Cost of Illness , Efficiency , Health Status , Occupational Health , Quality of Life , Schistosomiasis/epidemiology , Schistosomiasis/psychology , Absenteeism , Activities of Daily Living , Adult , Analysis of Variance , Attitude to Health , Case-Control Studies , Egypt/epidemiology , Female , Humans , Logistic Models , Male , Morbidity , Patient Admission/statistics & numerical data , Schistosomiasis/complications , Schistosomiasis/diagnosis , Severity of Illness Index , Sickness Impact Profile , Socioeconomic Factors , Surveys and Questionnaires , Textile IndustryABSTRACT
The effect of schistosomiasis on quality of life [QOL] and productivity of workers was examined. In a textile factory in Alexandria, Egypt, personal, occupational and sociodemographic data were collected from 172 workers with schistosomiasis and 172 workers without schistosomiasis. Several indicators of productivity and the World Health Organization QOL brief were used to determine the impact of schistosomiasis. The disease affected the general, physical and independence, psychological and spiritual, and social domains of QOL. Although the productivity score of workers with schistosomiasis did not differ significantly from the control group, they had significantly lower additional hours of work and lower total incentives/month. A significant relationship was found between severity of schistosomiasis and QOL domains and productivity indicators
Subject(s)
Activities of Daily Living , Analysis of Variance , Attitude to Health , Cost of Illness , Morbidity , Occupational Health , Surveys and Questionnaires , SchistosomiasisABSTRACT
All workers with schistosomiasis (205 workers) during the field period (April 1998 to March 1999) were included. The study tools included an interviewing schedule, the WHO QOL-brief and a production data format specially designed to obtain data about the productivity of the workers. The data revealed that 78.8% of the schistosomiasis workers suffered from Schistosoma mansoni while only 7.6% suffered from S. haematobium and 13.5% had a mixed infection. Workers infected with S. mansoni tended to have lower mean percent of all the QOL domains and productivity indicators compared with workers infected with S. haematobium but these differences were not statistically significant. Workers with complications of schistosomiasis had significantly lower values for the QOL physical, social relationship and environmental domains (55.27 +/- 15.59, 74.94 +/- 5.34 and 56.39 +/- 15.09 versus 61.38 +/- 5.74, 79.36 +/- 11.96 and 61.64 +/- 7.74 respectively). Moreover, the production score was significantly lower in the workers with complication compared with workers free from schistosomiasis complications. The mean percent of QOL domains decreased as the stage of schistosomiasis increased from stage 1 to stage 4, this was statistically significant for the physical and independence domain. The mean additional hours and production scores decreased successively from stage 1 to stage 4 of schistosomiasis. Thus, special attention should be paid to schistosomiasis workers for early detection and treatment of complications to improve the QOL and increase the productivity of those workers. The impact of the stage of schistosomiasis on productivity and QOL of workers needs further research with a wide spectrum of workload in different industries.
Subject(s)
Efficiency , Quality of Life , Schistosomiasis/classification , Schistosomiasis/physiopathology , Adult , Animals , Humans , Interviews as Topic , Male , Middle Aged , Occupations , Schistosoma haematobium , Schistosoma mansoni , Schistosomiasis/psychology , Surveys and QuestionnairesABSTRACT
Accidents are the leading cause of morbidity and mortality among schoolchildren. Epidemiological and risk predictors of injury severity were investigated among all school injuries presenting at the Students' Hospital in Alexandria during the scholastic year 1996-97. In all, 3422 injured pupils were surveyed. Age, nature of injury, place and mechanism of school injury and referral method were significant risk predictors for hospitalization. Age, referral method and nature of injury were significant predictors of referral to specialized health services. Injury severity score was significantly predicted by the presence of acute disease during time of injury, place and mechanism of injury as well as by provision of first aid and referral method and time.
