Subject(s)
Choroid Diseases/etiology , Granulomatous Disease, Chronic/complications , Retinal Diseases/etiology , Retinal Pigment Epithelium/pathology , Flow Cytometry , Fluorescent Dyes , Granulomatous Disease, Chronic/diagnosis , Humans , Male , Reactive Oxygen Species/metabolism , Rhodamines , Visual Acuity , Young AdultABSTRACT
Sleep deprivation (SD) following hippocampus-dependent learning in young mice impairs memory when tested the following day. Here, we examined the effects of SD on remote memory in both young and aged mice. In young mice, we found that memory is still impaired 1 mo after training. SD also impaired memory in aged mice 1 d after training, but, by a month after training, sleep-deprived and control aged animals performed similarly, primarily due to remote memory decay in the control aged animals. Gene expression analysis supported the finding that SD has similar effects on the hippocampus in young and aged mice.
Subject(s)
Aging/physiology , Memory Disorders/physiopathology , Memory, Long-Term/physiology , Sleep Deprivation/physiopathology , Sleep Deprivation/psychology , Animals , Gene Expression , Male , Mice, Inbred C57BL , Neuropsychological Tests , Time FactorsSubject(s)
Retinal Perforations/diagnosis , Retinoschisis/diagnosis , Vision Disorders/diagnosis , Adult , Blood-Retinal Barrier , Capillary Permeability , Electrophysiology , Endotamponade , Female , Fluorescein Angiography , Fluorocarbons/administration & dosage , Humans , Retinal Perforations/etiology , Retinal Perforations/surgery , Retinoschisis/complications , Tomography, Optical Coherence , Vision Disorders/etiology , Visual Acuity/physiology , Visual Fields/physiology , VitrectomyABSTRACT
PURPOSE: To compare the intermediate-term intraocular pressure (IOP) control and complication profile of the Ahmed Glaucoma Valve (AGV) implanted posteriorly through the pars plana in eyes undergoing concurrent pars plana vitrectomy (PPV) with device implantation in the anterior chamber (AC) in nonvitrectomized eyes. METHODS: : We retrospectively reviewed the medical records of 31 case eyes (30 patients) with refractory glaucoma that underwent posterior implantation of AGV after complete PPV and compared them to 31 control eyes (31 patients) with refractory glaucoma that underwent implantation of AGV in the AC. Case-control patients were matched one-to-one on the basis of principal glaucoma diagnosis. All surgeries were performed at 1 institution using a silicone-plate device. Success was defined as intraocular pressure (IOP)≥ 5 mm Hg and ≤ 21 mm Hg with or without glaucoma medications at final follow-up, no additional glaucoma surgery, no removal of the implant, and no loss of light perception. RESULTS: The average follow-up was 20.9 months (range, 6 to 54 mo) for the posterior group and 20.5 months (range, 4 to 48 mo) for the anterior group. The reduction in IOP was similar in both groups at all postoperative time points. The number of postoperative glaucoma medications in both groups was not statistically different at final follow-up. Success rates at final follow-up were identical, 83.9% in both groups, and Kaplan-Meier survival curve analysis showed no significant difference between the 2 groups (P=0.96). Postoperative complications were similar between the 2 groups, except there were more instances of early postoperative flat AC in the anterior group than the posterior group (P=0.01). CONCLUSIONS: The AGV can similarly control IOP in the majority of cases, whether the tube is placed in the posterior segment after PPV or in the AC of nonvitrectomized eyes.
Subject(s)
Anterior Chamber/surgery , Glaucoma Drainage Implants , Glaucoma/surgery , Posterior Eye Segment/surgery , Vitrectomy , Aged , Antihypertensive Agents/administration & dosage , Case-Control Studies , Female , Follow-Up Studies , Humans , Intraocular Pressure , Male , Postoperative Complications , Prosthesis Implantation/methods , Retrospective Studies , Treatment OutcomeABSTRACT
PURPOSE: To describe the course of a case of Castleman disease (CD) that presented with visual symptoms and retinal disease. METHODS: Clinical examination, fundus photography, and fluorescein and indocyanine green angiography were used to characterize the presence of bilateral exudative retinal detachments in a patient who was subsequently identified as having systemic lymphadenopathy. RESULTS: After an extensive medical workup including CT scans, blood testing, and a lymph node and renal biopsy, the patient was diagnosed with CD. Steroids were administered to treat CD. During the course of treatment, the patient developed renal failure, which was successfully treated with plasmapheresis. Four weeks later, the bilateral retinal detachments had resolved without local treatment. CONCLUSION: Exudative retinal detachments as manifestations of CD may be observed under systemic treatment for resolution before considering local therapy.
