1.
Antimicrob Agents Chemother
; 35(1): 188-91, 1991 Jan.
Article
in English
| MEDLINE
| ID: mdl-2014976
ABSTRACT
Multilamellar liposomal amphotericin B (L-AmB) was generally less active in vitro against yeast strains than was amphotericin B-deoxycholate or free amphotericin B, although continual agitation of the broth disproportionately increased the activity of L-AmB. Time-kill studies also demonstrated a slower onset of action of L-AmB and supported the hypothesis that liposomes may act as reservoirs for free amphotericin B, which is the active moiety.