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Biokhimiia ; 58(10): 1529-37, 1993 Oct.
Article in Russian | MEDLINE | ID: mdl-8268298

ABSTRACT

Cytochrome P-450scc from bovine adrenal cortex mitochondria was shown to be selectively phosphorylated by protein kinase C. The amino acid residues most accessible to phosphorylation by protein kinase C are located in the N-terminal sequence of cytochrome P-450scc. Adrenodoxin and cytochrome b5 protect cytochrome P-450scc from phosphorylation, this effect being dependent on the protein concentration.


Subject(s)
Adrenodoxin/pharmacology , Cholesterol Side-Chain Cleavage Enzyme/metabolism , Cytochromes b5/pharmacology , Protein Kinase C/metabolism , Adrenal Glands/enzymology , Amino Acid Sequence , Animals , Cattle , Cholesterol Side-Chain Cleavage Enzyme/chemistry , Microsomes/enzymology , Microsomes, Liver/enzymology , Molecular Sequence Data , Phosphorylation , Rabbits
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