Effect of Bioritm-E phytococktail and experimental medicinal drug from spurdog liver Skvaakan on microcirculation, platelet aggregation, and thromboresistance of vascular wall in rats.

The study compared the effects of phytococktail Bioritm-E (a multicomponent phytoadaptogen) and experimental preparation Skvaakan from the liver of Black Sea spurdog on systemic homeostasis, microcirculation, and blood lipid profile in 15 days of their daily administration. Skvaakan enhanced the platelet activity producing no effect on vascular thromboresistance. Bioritm-E phytococktail inhibited platelet activity and enhanced vascular thromboresistance. Both agents modified blood lipid profile by decreasing concentration of triglycerides and HDL; in addition, they strengthened the vascular wall and increased vascular resistance. These findings attest to similarity of some biomedical features of phytoadaptogen Bioritm-E and hydrobiont Skvaakan, although they produced different biological effects on platelet activity and vascular thromboresistance.

[Optimization of sanatorium treatment of patients with essential hypertension stage II by chronotherapy]. / Optimizatsiia sanatorno-kurortnogo lecheniia bol'nykh gipertonicheskoi bolezn'iu II stadii metodami khronoterapii.

A comprehensive chronodiagnostic examination and treatment were performed in 45 patients with essential hypertension stage II aged 37 to 68 years taking 21-day treatment at sanatorium Osetia. The patients were divided into 2 groups: 20 patients of group 1 received basic antihypertensive treatment (enap, hypothiaside) and sulfurated hydrogen balneotherapy not adjusted to individual biorhythm; 25 patients of group 2 received the same treatment by adjusted to biorhythmic phases of basic cardiovascular indices and chronotype established according to Estberg's questionnaire. Estimation of the rhythms of the integral indices of physiological functions (systolic and diastolic arterial pressure, heart rate, body temperature) and "individual minute" was made within 3 days in 4-h intervals. Hemodynamics was studied before and in the end of the treatment with echocardiography, dopplerechocardiography and rheoencephalography. Positive shifts were registered in both groups: a significant fall in arterial pressure, total peripheral vascular resistance, double product and cardiac performance. Patients of group 2 had greater number of significant rhythms of physiological function parameters, primarily circadian, more frequent recovery of amplitude and phase parametric characteristics, better improvement of cerebral circulation, contractile and diastolic functions of the myocardium, reduction of the required medication doses and 2-fold lowering of side effects rate.

[Assessment of time-dependent effects of long-acting altiazem in patients with hypertension stage II]. / Otsenka vremiazavisimykh éffektov altiazema prolongirovannogo deistviia u bol'nykh gipertonicheskoi bolezn'iu II stadii.

A chronodiagnostic examination covered 27 patients with hypertension stage II of indifferent chronotype. The patients were divided into 3 groups by the time of intake of a single daily dose of altiazem--at 8 a.m., 14 p.m., 20 p.m. Chronological organization of the cardiovascular system was studied with autorhythmometry for 3 days in 4-h intervals including night before and in the end of the treatment. Echo-CG, doppler echocardiography and rheoencephalography investigated hemodynamics once daily also before and in the end of the treatment. The findings show advantage of chronotherapeutic prescription of altiazem PP in a mean dose 220 mg/day at evening hours in non-chronodependent patients with hypertension stage II because such a regimen brought about more adequate restoration of the cardiovascular system time organization both by the spectrum of significant rhythms and their parameters; by better improvement of left ventricular diastolic function and pulse cerebral flow. Faster achievement of the therapeutic effect in the evening intake of altiazem supports its chronotherapeutic administration. This leads to reduction of the drug course dose and, therefore, treatment duration.

[Chrono-ecological analysis of population health and ways of its recreation]. / Khronoékologicheskii analiz sostoianiia zdorov'ia naseleniia i sposoby ego rekreatsii.

Reported are results of multiyear observation of the structure of individual and population health in Vladikavkaz, and the authors' concept of health recovery and protection through application of modern high technologies of active chronoadaptation to extreme living conditions. The proposed methods of active chronoadapation, i.e. phytocorrection and phytopro-phylaxis, reflexocorrection, bioradiological correction, bioresonance chronolasercorrection can be also of interest for aerospace medicine.

[Effects of Eleutherococcus on the biorhythm of indices of peripheral blood in dogs]. / Vliianie éleuterokokka na bioritmy pokazatelei perifericheskoi krovi sobak.

The circadian rhythms of the erythrocytes, hemoglobin and leucocytes concentration in the peripheral blood in dogs in winter and the effect of the eleutherococcus multi-injected at different periods of the day, were studied. The changes in the parameters of the studied biorhythms indices were observed only in the after dinner-injected animals, they being marked by the evident increase of the mesor and amplitude, acrophase shift by 1-2 hours by the beginning of the twenty-four hours.

[The biological rhythms of the hemostatic system in dogs]. / Issledovanie biologicheskikh ritmov sistemy gemostaza sobak.

Temporal organization of the system of coagulative hemostasis was studied with the help of group and individual chronoanalysis examining the marks, characterising its basic functional blocks. The trustworthy ultra-, circa- and infradian rhythms of the components in two types of the intrasystemic organization were brought to light: the type during which the rhythms of all stages of the process were synphased and the type of time correlation during which the marks of the coagulative and post-coagulative stages of the process of coagulation were antiphased.