ABSTRACT
Within the limits of experimental supervision the estimation of hypolipidemic action of the complex emulgator-stabilizer (CES) on the basis of a water extract from roots of strange (alien) Saponaria officinalis L and laminal in the ratio 1:1,5 has been made. The received results allow to recommend the CES as a complex food additive at infringements of lipide exchange, especially connected with development hyper-cholesterinemia.
Subject(s)
Eukaryota , Hypercholesterolemia/drug therapy , Hypolipidemic Agents/pharmacology , Phytotherapy , Plant Extracts/pharmacology , Plant Roots , Saponaria/chemistry , Animals , Eukaryota/chemistry , Hypolipidemic Agents/chemistry , Lipid Metabolism/drug effects , Male , Phytotherapy/methods , Plant Roots/chemistry , RatsABSTRACT
Within the limits of experimental observation the assessment of acute and subacute safety of an aqueous extract from Acanthophyllum roots with a solids content of 7%, used as an emulsifier has been manufactured by production of emulsion products. Acute toxicity (LD50) AEAR, probed on mice-male; has allowed to refer to an emulsifier to a class of nontoxic substance. The assessmentof subacute toxicity of an extract (injection in a food allowance within 30 days in a recommended dose--5 ml on 100 g of a standard food allowance) was spent on laboratory rats. Extent of toxicity of a specimen judged on the general state of animals, a body mass dynamics, internals masses, to biochemical parameters of blood plasma, parameters of a peripheric blood, a morphological pattern of an internals. Comparative analysis of results allows to expel toxic effect AEAR in the recommended dose on an organism of animals.
Subject(s)
Emulsifying Agents/toxicity , Plant Extracts/toxicity , Saponaria/chemistry , Vegetables/chemistry , Animals , Blood/metabolism , Dose-Response Relationship, Drug , Lethal Dose 50 , Male , Mice , Plant Roots/chemistry , Rats , Rats, Wistar , Toxicity TestsABSTRACT
In the researches which have been lead on white not purebred rats--mans on model nutritional hyperlipoproteinemia it fixed hypolipidemic activity of a water extract from roots carline thistle with the content of dry solvends of 7% which.