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Bioorg Khim ; 37(2): 253-8, 2011.
Article in Russian | MEDLINE | ID: mdl-21721258

ABSTRACT

Earlier unknown 1,8-diamino-3-methyl-4-azaoctane (gamma-MeSpd) was synthesized. The analogue was not a substrate of ether spermine/spermidine N1-acetyltransferase, or spermine synthase, but was capable to support the growth of DU145 cells with depleted polyamine pool. Such a combination of y-MeSpd properties discloses novel opportunities to study cellular functions of catabolically unstable and easily interconvertible spermine and spermidine.


Subject(s)
Biomimetic Materials/chemical synthesis , Prostatic Neoplasms/metabolism , Protein Stability , Spermidine/chemical synthesis , Spermine/metabolism , Acetyltransferases/metabolism , Cell Growth Processes/drug effects , Cell Line, Tumor , Humans , Male , Prostatic Neoplasms/pathology , Spermidine/analogs & derivatives , Spermidine/metabolism , Spermidine/pharmacology , Spermine Synthase/metabolism , Substrate Specificity
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