[The clinical characteristics of progressive focal epilepsy with a herpetic etiology]. / Klinicheskie osobennosti progressiruiushchei fokal'noi épilepsiei gerpeticheskoi étiologii.

Cases are described of chronic zoster encephalitis presenting with the leading progressive focal epilepsy syndrome. The clinical presentation of the trouble can include both general cerebral signs and those of the focal affection of the central nervous system only. The progressive course and duration of remission suggest to us a persisting infection manifesting against the background of immune deficiency.

[The characteristics of progressive dementias in patients with herpetic encephalitis]. / Osobennosti progressiruiushchikh dementsii u bol'nykh gerpeticheskim éntsefalitom.

9 lethal cases of progressive dementias were analysed, both psychical and neurological disturbances characteristics on different stages of herpetic dementias were presented, a number of clinical morphological criteria of diagnosis ascertaining was described. It was determined that progressive dementias turned out to be one of the clinical forms of chronic CNS herpetic infection which was conditioned by prolonged persistence and activation of herpes simplex virus in brain tissue.

[The efficacy of an antiviral factor obtained from infected chick embryo fibroblasts in an experimental herpetic infection]. / Effektivnost' antivirusnogo faktora, poluchaemogo iz infitsirovannykh fibroblastov kurinogo émbriona, pri éksperimental'noi gerpeticheskoi infektsii.

Treatment of mice with an antiviral factor obtained from the culture medium of infected chick embryo fibroblasts protected them against lethal meningoencephalitis caused by herpes simplex virus. The degree of protection varied from 50 to 75% depending on the virus dose, the route of infection, and the mode of the antiviral factor application.

[Chronic herpetic encephalitis with a progressive epileptic syndrome]. / Khronicheskii gerpeticheskii éntsefalit s progressiruiushchim épileticheskim sindromom.

Basing on the evidence provided by clinicomorphological and immunobiological studies, three, patients with progressive epileptic seizures were found to have chronic herpetic inflammation in the brain. The seizures took serial pattern with development of status epilepticus.

[The clinico-pathogenetic characteristics of Kaposi's sarcoma]. / Kliniko-patogeneticheskie osobennosti sarkomy Kaposhi.

The paper is concerned with clinicomorphological characteristics of endemic, immune and epidemic (AIDS-associated) forms of Kaposi's sarcoma (KS). Recent experimental and clinical evidence suggests pathogenic contribution to KS of virus-induced depression of sex-linked genes and immunosuppression. Combined action of these factors should be regarded when specifying current presentation of KS.

[Clinical forms of acute herpetic infections of the central nervous system in adults]. / Klinicheskie formy ostrykh gerpeticheskikh porazhenii tsentral'noi nervnoi sistemy u vzroslykh.

The authors describe the course of herpetic encephalitis in 52 patients aged 16 to 64 years. Five types of the initial manifestations of herpetic infection of the CNS were revealed. In 44.3% of cases the disease started from the general cerebral symptomatology and consciousness disturbance; in 13.6% it started in a brain stroke-like manner followed by the development of the comatose status; in 13.6% of cases from memory disorder and unmotivated actions; in the same percentage of cases, the disease onset was marked by the dominance of dizziness, diplopia, ataxia and central hemiplegia ; in 15.9% the disease started from pains in the stomach, loin and lower limbs. Hemispheric and pseudotumorous stem encephalitides (48.1 and 13.6% respectively) were predominant; in 25% meningoencephalitides and in the remainder, encephalomyelitis running their course in the form of disseminated encephalomyelitis (5.7%), focal myelitis (5.7%) or opticomyelitis (1.9%). The data presented attest to the pleomorphism of the clinical picture of herpetic lesions of the CNS.

[Chronic forms of herpetic lesions of the central nervous system in adults (clinico-laboratory and morphological studies)]. / Khronicheskie formy gerpeticheskikh porazhenii tsentral'noi nervnoi sistemy u vzroslykh (kliniko-laboratornye i morfo- logicheskie issledovaniia).

Based on analysis of 17 cases with chronic herpetic encephalitis and encephalomyelitis, the authors demonstrate the diversity of the clinical manifestations of the illnesses. A problem of the progredient forms of those neurologic infections is discussed.

[Antiviral factor isolated from infected cell cultures]. / Antivirusnyi faktor, vydeliaemyi iz infitsirovannykh kul'tur kletok.

An antiviral factor of protein nature inhibiting reproduction of VEE, herpes, vaccinia VSV, fowl plague viruses was isolated from infected cell cultures. The factor has no virucidal or prophylactic effect, stable to low pH values and heating at 100 degrees C for 30 min.