[Scientific-Pedagogic School of Biological and Medical Chemistry of the O. O. Bogomolets National Medical University (on the 160th year of its founding)]. / Naukovo-pedahohichna shkola biolohichnoï ta medychnoï khimiï Natsional'noho medychnoho universytetu im. O. O. Bohomol'tsia (do 160-richchia zasnuvannia).

In this work the most important stages of the scientific-pedagogic school of biologic and medical chemistry formation in Bogomolets National Medical University starting from the period of foundation as early as in 1863 till nowadays the Chair of Medical Chemistry and Physics as a part of Medical Faculty of Saint Volodymyr Emperor University in the city of Kyiv have been estimated and generalized. The especial attention is attracted to the fact, that it was Kyiv University where firstly the Chair of Biochemistry was created in order of stuyding the regularities of biochemical processes running in the human organism and metabolism disturbances inducing the pathologic processes at some diseases. The scientific and scientific-pedagogical trends of the chair work in different periods of its development are presented, simltneously the leading role of famous Ukrainian scientists--biochemicians in foundation and development of biologic and medical chemistry scientific school in the University are emphasized. Nowadays the Chair is the educational and scientific center supporting and developing the best traditions on training the specialists of different qualification levels: physicians Masters of Science, Philosophy Doctors and Doctors of Science in Medicine and Biology. The Chair is considered to be a basic one among the Ukraine higher medic and pharmaceutic educational institutions having the III-IV accreditation rate on the problems of teaching-organizational, educational-methodical and scientific work. On the Chair base there is functioning the Scientific Problem-Solving Commission of Ministry of health Protections of Academy of Medical Sciences of Ukraine "Biological and medical Chemistry" (the chairman is the Corresponding-Member of Academy of Medical Sciences of Ukraine, Prof. Yu.I. Gubsky. The Chair personnel compiled and issued the contemporary manuals in Ukraine language on Biologic and Bioorganic Chemistry.

[NADH as a substrate of enzymatic lipid peroxidation]. / NADH iak substrat fermentatyvnoho perekysovoho okyslennia lipidiv.

The existence of enzymatic NADH-dependent peroxidation of lipids has been established. Some its characteristics in comparison with nonenzymatic ascorbate-dependent and enzymatic NADPH-dependent lipid peroxidation have been found. Some reactions of enzymatic peroxidation of lipids (NADPH- and NADH-dependent) in contrast to nonenzymatic (ascorbate-dependent), is not inhibited by the electron carriers (methylene blue and vikasol). This part of lipid peroxidation is not affected by hypoxia and combined effect of hypoxia as well as the action of carbon oxide (II) both separate and in combination with the electron carriers.

[Antioxidant properties of pharmacopoeia drugs--derivatives of the phenothiazine series]. / Antioksidantovi vlastyvosti farmakopeiovykh preparativ-- pokhidnykh fenotyazynovoho riadu.

Some pharmaceutical drugs--phenothiazine derivates--which have antioxidant properties were studied. One cannot eliminate the possibility, that such an effect of these drugs plays certain part in their action mechanism. Possible mechanisms of antioxidant effect of the drug are discussed proceeding from the study of kinetics of reactions of NADPH- and ascorbate-dependent peroxidation of lipids. There is a theoretical substantiation of the first-hand application of phenothiazine derivatives (among other neuroleptics) under the correction of psychoemotional stress and other states accompanied by the increase of lipid peroxidation.