[The immunomodulating action of the surface antigens of the influenza A virus in experimental staphylococcal infection]. / Immunomoduliruiushchee deistvie poverkhnostnykh antigenov virusa grippa A pri éksperimental'noi stafilokokkovoi infektsii.

The results of the study of influenza A virus surface antigens, hemagglutinin and neuraminidase, in the induction of nonspecific immunomodulation and protection from acute pulmonary staphylococcal infection have been studied. Protective effect, the cell composition of bronchoalveolar lavage fluid depend on the serological subtypes of surface antigens used for intranasal immunization and the infective dose of staphylococci.

[Contamination of fish tissue cell cultures by Mycoplasma]. / Mikoplazmennaia kontaminatsiia kul'tur kletok iz tkanei ryb.

The inoculated and primary cell cultures of fish (carp, salmon, and sturgeon) have been studied. Acholeplasma typed as A. laidlawii in terms of its biochemical properties shown in inhibited metabolism has been isolated from 19 samples. The authors consider the source of Acholeplasma-induced contamination of the cell cultures under study.

[Suppressive action of the influenza virus on the bone marrow stem cells of mice]. / Supressivbnoe deistvie virusa grippa na stvolovye kletki kostnogo mozga myshei.

The effect of pathogenic and noninfectious influenza viruses with different surface antigens on colony-forming stem cells of (CBA X C57BL/6)F1 mice was studied. Bone marrow cells were infected with A/PR8/34 (H1N1)/A/Krasnodar/101/59 (H2N2) viruses, a recombinant A/PK-6-3 (H2N1) strain thereof, A/Khabarovsk/933/77 (H1N1) strain; then they were inoculated intravenously to irradiated (820 rad) syngeneic recipients, and colony-forming units (CFU) were determined in the spleens 9 days after injection. Inoculation of bone marrow cells (2 X 10(5) per mouse) to the irradiated recipients immediately after mixing with a live A/Krasnodar virus heated at 56 degrees C, live A/PK-6-3, and A/Khabarovsk viruses resulted in suppression of formation of CFU and marked atrophy of the recipients' spleens. There was no suppression after the use in these experiments of the pathogenic A/PR/8/34 strain. Inhibition of CFU production in the spleen was observed after inoculation of the recipients with bone marrow cells incubated for 1 hour at 37 degrees C with A/PR/8/34, A/Krasnodar/101/59 viruses and the recombinant strain. Possible mechanisms of the suppressive effect of influenza A virus on CFU production in mice are discussed.

[Cytotoxic activity of normal killers and the lymphocytic proliferative response to specific viral antigens in influenza in mice]. / Tsitotoksicheskaia aktivnost' normal'nykh killerov i proliferativnyi otvet limfotsitov na spetsificheskie virusnye antigeny pri grippoznoi infektsii u myshei.

Inoculation of CBA mice with pathogenic influenza A/PR8/34 (H1N1) virus and non-pathogenic A/Krasnodar/101/59 (H2N2) virus demonstrated that the pathogenic strain enhanced the synthesis of serum interferon and activated the function of normal killers, but had a relatively low capacity of causing in vitro proliferative response of spleen lymphocytes of intact and in vivo primed animals. In contrast, the nonpathogenic virus had less marked interferon-inducing capacity and that of activating normal killers, but induced a very high proliferative response of lymphocytes in culture.

[Effect of the host's body genotype and phenotype on the manifestation of the pathogenic properties of the influenza virus]. / Vliianie genotipa i fenotipa organizma khoziaina na proiavlenie patogennykh svoistv virusa grippa.

The sensitivity of mice of CBA (H-2k haplotype), C57BL/6 (H-2b haplotype) strains and their hybrids M1 and F2 to the pathogenic influenza A/PR8/34 (H0N1) and nonpathogenic A/Krasnodar/101/59 (H2N2) virus strains was studied. The lethality, virus replication in the lungs, and the thymic index were determined. An increase in the resistance to the pathogenic influenza virus was found in male C57BL/6 and male F1 (CBA X C57BL/6) hybrids in the summer period as compared with winter. Replication of the pathogenic virus in the lungs of mice, in contrast to the nonpathogenic one, was accompanied by marked atrophy of the thymus. The study suggests the existence of a certain association between the resistance to influenza infection and phenotypic changes in the host connected with the weight of the thymus and the presence of mature T-lymphocytes.