[Multiple gliomas]. / Mnozhestvennye gliomy.

The authors present 2 patients. One of them had typical multifocal primary multiple synchronous wild-type IDH1/2 glioblastoma subtype RTK1, chromosome 7 duplication, homozygous CDKN2A deletion and chromosome 10 deletion. In another patient, the nature of tumors remains debatable. We can talk about either a rare atypical case of metachronous multicentric various glial tumors (oligodendroglioma, IDH1-mutant and 1p/19q-codeleted, WHO grade 2 and RTK2-glioblastoma) or secondary glioblastoma after previous oligodendroglioma arose a year after radiotherapy.

[The early and subclinical forms of cerebrovascular pathology in patients with chronic ischemic heart disease]. / Rannie i subklinicheskie formy tserebrovaskuliarnoi patologii u bol'nykh khronicheskoi ishemicheskoi bolezn'iu serdtsa.

The results of a cardioneurological follow-up enabled the authors to develop the principles of the angioneurological evaluation of patients with chronic coronary heart disease (CCHD). The survey covered 118 CCHD males aged 40-59 of functional class I and II. A differential complex of tests involving neuropathological and neuropsychological examinations, rheoencephalography with pharmacological and bicycle ergometry tests, biomicroscopy of bulbar conjunctiva allows early detection of subclinical and initial manifestations of cerebral circulatory failure (CCF) in CCHD patients. Quantitation of cerebral circulation at graded exercise test according to specially devised criteria is intended for differentiation of subclinical CCF in CCHD patients from age-specific changes in cerebral vessels and residual brain pathology of nonvascular genesis. Using a discriminant analysis of risk factors, ECG and echo-CG findings, the authors have designed a method of predicting dyscirculatory encephalopathy in CCHD patients free of cerebrovascular symptoms. The method can contribute to advanced efficacy of preventive and therapeutic measures in coronary patients.

[Use of hyperbaric oxygenation in the treatment of acute cerebrovascular disorders in ischemic heart disease]. / Primenenie giperbaricheskoi oksigenatsii v lechenii ostrykh tserebrovaskuliarnykh rasstroistv pri ishemicheskoi bolezni serdtsa.

Altogether 22 patients with concomitant cardio-cerebral acute pathology underwent all-round examinations during and after sessions of hyperbaric oxygenation (HBO). The highest clinical effect was produced by minor, substituting doses of HBO. The revealed phasic nature of the action of HBO in the treatment of patients with acute large-focal myocardial infarction and acute cerebrovascular disorders was found to be due to changes in the function of diencephalic and brain stem formations, determining the decrease of adaptation potentialities in this patients' group. HBO was found to be clinically effective in the treatment of such patients. In order to raise the treatment efficacy, it is necessary that an individual approach be exercised in the choice of therapeutic HBO sessions.

[Changes in systemic and regional hemodynamics in the acute period of myocardial infarction in conscious rabbits]. / Izmeneniia sistemnoi i regionarnoi gemodynamiki v ostrom periode infarkta miokarda u bodrstvuiushchikh krolikov.

Systemic and regional hemodynamics (radioactive microspheres of 15 mcm) were studied in 7 conscious immobilized rabbits 30 min, 24 and 72 hours after left coronary artery occlusion (group 1) and 30 min and 24 hours after the occlusion in 5 rabbits who died the next day (group 2). Significant changes in myocardial blood flow, white cerebral matter and kidneys were only observed 24 h after coronary artery occlusion in group 2, simultaneously with a significant (29%) decrease in cardiac output. It is suggested that significant regional blood flow changes associated with acute experimental myocardial infarction only occurred in the presence of heart failure in rabbits.

[Antifibrillatory effect of the calcium antagonist foridon in acute myocardial ischemia in conscious rabbits]. / Antifibrilliatornoe deistvie antagonista kal'tsiia foridona pri ostroi ishemii miokarda u bodrstvuiushchikh krolikov.

The effect of ryodipine on disorders of rhythm induced by occlusion of the left descending coronary artery was studied in experiments on 40 conscious immobilized rabbits. Ryodipine was injected intravenously (50 mcg/kg 5 minutes prior to and 25 mcg/kg after occlusion). Ventricular fibrillation developed in 19 (66%) rabbits of the control group and in 3 (27%) animals in the experimental group (p less than 0.03). The parameters of systemic and regional hemodynamics were studied in 7 rabbits of the control group and in 5 animals of the experimental group before and 30 minutes after occlusion; microspheres (15 mcm) labelled with various radioactive isotopes were used in the study. The blood flow in the intact myocardium of rabbits given ryodipine was higher than the initial level by 14% (p less than 0.05). The coronary fraction of the cardiac output increased by 21%. It is concluded that the antifibrillation effect of ryodipine is due to its favourable action on the myocardial blood flow.

[Status of the mnestic function of ischemic heart disease patients]. / Sostoianie mnesticheskoi funktsii u bol'nykh ishemicheskoi bolenzn'iu serdtsa.

Mnemonic function was studied in 105 males with chronic coronary heart disease (CCHD). A reduced volume of memory and intensified inhibition of trace formation was observed in more than 75% of the patients. The degree of memory disorders depended on the form of the CHD course. A combination of drugs dilating the heart vessels with drugs improving metabolism and the brain blood flow resulted in an improvement of mnemonic function.