ABSTRACT
Multiple endocrine neoplasia (MEN) syndrome--is a hereditary disease which is characterized by synchronous or metachronous development of benign (adenoma, hyperplasia) or malignant tumors in the endocrine organs. The presence of medullary thyroid carcinoma and pheochromocytoma are mandatory requirements of MEN 2 syndrome. The purpose of our study was to perform timely diagnosis and optimal surgical treatment of patients with MEN 2 syndrome. Over the 1999-2009 years in the clinic we have diagnosed the MEN 2 syndrome in 5 patients, of whom two women were sisters. In all patients we observed medullary thyroid carcinoma and pheochromocytoma. Two patients had bilateral pheochromocytoma, and the clinical course was characterized with mild arterial hypertension. Primary hyperparathyroidism was observed in 2 patients. In the near relatives of patients with MEN 2 syndrome it must measure calcitonin, catecholamines, calcium rate, conduct ultrasound examination of the neck and retroperitoneal space.
Subject(s)
Adrenal Gland Neoplasms/diagnosis , Hyperparathyroidism/diagnosis , Hypertension/diagnosis , Multiple Endocrine Neoplasia Type 2a/diagnosis , Pheochromocytoma/diagnosis , Thyroid Neoplasms/diagnosis , Adrenal Gland Neoplasms/blood , Adrenal Gland Neoplasms/complications , Adrenal Gland Neoplasms/surgery , Adult , Biomarkers/blood , Calcitonin/blood , Calcium/blood , Carcinoma, Neuroendocrine , Catecholamines/blood , Female , Humans , Hyperparathyroidism/blood , Hyperparathyroidism/etiology , Hyperparathyroidism/surgery , Hypertension/blood , Hypertension/etiology , Hypertension/surgery , Male , Multiple Endocrine Neoplasia Type 2a/blood , Multiple Endocrine Neoplasia Type 2a/complications , Multiple Endocrine Neoplasia Type 2a/surgery , Pheochromocytoma/blood , Pheochromocytoma/complications , Pheochromocytoma/surgery , Siblings , Thyroid Neoplasms/blood , Thyroid Neoplasms/complications , Thyroid Neoplasms/surgeryABSTRACT
During the last years for surgical treatment of primary hyperparathyroidism minimally invasive operations were applied. The results of the introduction of video-assisted parathyroidectomy in the clinic in 8 (32%) of 25 patients with primary hyperparathyroidism, who were operated during the 2010-2012 were analysed. Video-assisted parathyroidectomy compared to conventional operation allowed to reduce significantly the duration of the operation, to reduce the incidence of postoperative complications, to achieve a better cosmetic effect.
