ABSTRACT
A lethal case is reported of chronic Q-fever in a patient aged 34 who regarded himself as completely healthy six months before his death. The diagnosis was made on the basis of vital investigation of blood sera in a complement-fixation test and indirect fluorescent-antibody test (antibody titers 1 : 1280 against phase 1 and 1 : 320 against phase 2 Coxiella burnetii), differentiation of antibodies as distinct classes of immunoglobulins, results of pathoanatomical and microbiological investigations. Pathoanatomical features of the organs are fully detailed, especially those of the heart. Death occurred in the presence of cardiac failure growing progressively worse, involving many organs. Patients with cardiovascular pathology have to be examined for Q-fever in order that we should be able to early detect and apply specific therapy to treat its chronic form.
Subject(s)
Endocarditis, Bacterial/etiology , Heart Failure/etiology , Q Fever/complications , Adult , Chronic Disease , Endocarditis, Bacterial/pathology , Fatal Outcome , Heart Failure/pathology , Humans , Male , Myocardium/pathology , Q Fever/pathology , Rheumatic Heart Disease/complications , Rheumatic Heart Disease/pathologyABSTRACT
On the basis of experimental studies it was established, that the threshold concentration of 3-phenoxybenzyl chloride (PBC) according to the influence on organoleptic water properties (odour) is 0.03 mg/l, on the sanitary regimen of water reservoirs (BOD inhibition)--0.3 mg/l. The chemical produces low toxicity when administered parenterally, it is highly toxic when administered subcutaneously; cumulation degree is medium. PBC produces a weak allergic effect, an expressed embryotoxic effect; mutagenic activity was not detected. The maximal no-effect dose according to the embryotoxic effect is 0.12 mg/kg (2.4 mg/l), the calculated maximal no-effect concentration is 0.11-0.34 mg/l when administered subcutaneously. The recommended MAC is 0.03 mg/l according to the organoleptic index of harmfulness (odour) with a note 'dangerous when administered through skin' (the third class of danger).
