ABSTRACT
The results of the study of the autopsy materials from 61 patients with the diagnosis of pneumonia received by virological and genetic methods are reviewed. The materials were studied at the Influenza Etiology and Epidemiology Center of the Ivanovsky Institute of Virology, Ministry of Health and Social Development of the Russian Federation, during epidemic seasons 2009-2010 and 2010-2011. The data were analyzed with respect to age, sex, comorbidity diseases and identified on the groups of the risk of severe forms of the disease. The presence of the pandemic influenza virus strain RNA was confirmed in 70.5% of materials; RNA of influenza B was detected in 1.2% cases. The co-infections caused by the bocavirus, adenovirus, parainfluenza virus type 2 and 4, rhinovirus, and streptococcus were detected only in 19.7%. In most cases, the influenza virus was the etiologic agent of lethal pneumonia, which justifies the necessity of the early etiological diagnosis and treatment with antiviral drugs.
Subject(s)
Influenza A Virus, H1N1 Subtype/isolation & purification , Influenza, Human/complications , Pandemics , Pneumonia, Viral/etiology , RNA, Viral/isolation & purification , Adenoviridae Infections/epidemiology , Adenoviridae Infections/mortality , Adenoviridae Infections/virology , Adolescent , Adult , Aged , Autopsy , Child , Child, Preschool , Coinfection , Female , Humans , Infant , Influenza A Virus, H1N1 Subtype/classification , Influenza A Virus, H1N1 Subtype/genetics , Influenza, Human/epidemiology , Influenza, Human/mortality , Influenza, Human/virology , Male , Middle Aged , Picornaviridae Infections/epidemiology , Picornaviridae Infections/mortality , Picornaviridae Infections/virology , Pneumonia, Viral/epidemiology , Pneumonia, Viral/mortality , Pneumonia, Viral/virology , RNA, Viral/classification , RNA, Viral/genetics , Russia/epidemiology , Streptococcal Infections/epidemiology , Streptococcal Infections/microbiology , Streptococcal Infections/mortalityABSTRACT
Disorders of apoptosis regulation leading to development oftumours associated with expression of one of the main links in the regulation of programmed death of cells (proteins of the Bcl-2 family) were studied.
Subject(s)
Apoptosis , Neoplasms/metabolism , Proto-Oncogene Proteins c-bcl-2/metabolism , Animals , Humans , Neoplasms/genetics , Neoplasms/pathology , Proto-Oncogene Proteins c-bcl-2/geneticsSubject(s)
Antibiotics, Antitubercular/pharmacology , Antitubercular Agents/pharmacology , Isoniazid/pharmacology , Mycobacterium tuberculosis/drug effects , Mycobacterium tuberculosis/genetics , Rifampin/pharmacology , Tuberculosis/drug therapy , Adjuvants, Immunologic/administration & dosage , Animals , Antibiotics, Antitubercular/therapeutic use , Antitubercular Agents/therapeutic use , BCG Vaccine/administration & dosage , BCG Vaccine/immunology , Female , Genetic Engineering , Humans , Isoniazid/therapeutic use , Male , Mice , Mutation , Polymorphism, Genetic , Rifampin/therapeutic use , Risk Factors , Tuberculosis/genetics , Tuberculosis/immunology , Tuberculosis/prevention & controlABSTRACT
The effect of pathogenetic therapy in the normalization of homeostasis disturbances in monkeys has been shown under experimental conditions. Data on the possibility of using hemosorption in the treatment of severe forms of glanders are presented. The conclusion on the necessity of using complex treatment for the effective therapy of glanders in humans has been made.
Subject(s)
Burkholderia Infections/therapy , Glanders/therapy , Monkey Diseases/therapy , Papio , Acute Disease , Animals , Biomarkers/blood , Burkholderia Infections/blood , Burkholderia Infections/etiology , Burkholderia Infections/immunology , Cell Migration Inhibition , Combined Modality Therapy , Disease Models, Animal , Glanders/blood , Glanders/etiology , Glanders/immunology , Hemoperfusion/instrumentation , Hemoperfusion/methods , Male , Monkey Diseases/blood , Monkey Diseases/etiology , Monkey Diseases/immunologyABSTRACT
Some aspects of homeostasis impairment in monkeys infected with Pseudomonas mallei were investigated. The levels of the hormonal shifts, complement components, beta 2-microglobulin and prostaglandins evident of the infection severity were estimated. The pathomorphological profiles of various forms of malleus in the primates were studied.
Subject(s)
Disease Models, Animal , Glanders/physiopathology , Homeostasis , Monkey Diseases/physiopathology , Papio , Animals , Female , Glanders/diagnosis , Glanders/metabolism , Glanders/pathology , Male , Monkey Diseases/diagnosis , Monkey Diseases/metabolism , Monkey Diseases/pathology , Prognosis , Time FactorsABSTRACT
Using the radioreceptor method thymosin fraction 3 was demonstrated to displace 3H-morphine and 3H-naloxone from opiate receptor of crude membrane fraction of the rat brain. The value of EC50 ratio in the presence and absence of 100 mM NaCl seems to indicate that thymosin contains one or several partial agonists of morphine. Furthermore, the peptide nature of these ligands is suggested on the basis of enzymatic treatment data. The possible role of opioid peptides in the realization of thymus endocrine functions is discussed.
