[Production of fibrous materials, containing an immobilized proteolytic enzyme and urea]. / Poluchenie voloknistykh materialov, soderzhashchikh immobilizovannyi proteolitichskii ferment i mochevinu.

Immobilization of cellulose and polyacrylic acid on a grafted copolymer increased significantly the stability of proteolytic enzymes to inactivation by urea. Materials containing immobilized proteolytic enzymes and urea and displaying a combined biological activity were obtained.

[Preparation of films with combined biological activity and study of their properties]. / Poluchenie plenok s kombinirovannym biologicheskim deistviem i issledovanie ikh svoistv.

Joint immobilization of a proteolytic enzyme (terrilytin, protease C, or collytin) and an antimicrobial compound or the bacteriolytic enzyme lysozyme in the structure of polyvinyl alcohol was studied. Changes in the activity of immobilized enzymes upon x-ray sterilization were studied. These materials were highly effective in wound healing.

[Preparation of films and fibers containing proteolytic enzymes]. / Poluchenie plenok i volokon, soderzhashchikh proteoliticheskie fermenty.

Immobilization of the proteolytic enzymes trypsin and terrylitin in fluorplastic-42 films and fibers as well as in water-soluble polymeric (polyvinyl alcohol and carboxymethyl cellulose) films was being studied during preparation of the films. The properties of the proteolytic enzymes immobilized in the polymers are dependent on the conditions of preparation of fibers and films.

[Modification of the properties of drugs combined with polymers. II]. / Modifikatsiia svoistv lekarstvennykh veshchestv putem prisoedineniia ikh k polimeram. Chast' II.

In the second part of the paper there have been discussed the works on modification of drugs properties when coupled with polymers in terms of covalent links. It was proved on a number of cases that chemical bonds of specified drugs and polymers allows to increase the durability and effective action of these remedies, to decrease the toxicity, to increase the solubility and immunity against ferments and, moreover, enable the advantageous disposal of these substances in particular organs.

[Modification of properties of drugs combined with polymers. I]. / Modifikatsiia svoistv lekarstvennykh veshchestv putem prisoedineniia ikh k polimeram. Chast' I

The article reviews the papers on modifying the properties of drugs by their administration in the form of a mixture with polymers, or combination of the drugs and polymers using coordinative or ionic bonds. In many cases the combination of drugs and polymers by chemical means or preparation of a mixture of drugs and polymers prolongs and increases the effectivity of drugs, increases their solubility, decreases their toxicity, and modifies their distribution in the organs.