[The effect of hydra peptide morphogen on the levels of beta-endorphin and some blood and adrenal hormones in albino rats]. / Vliianie peptidnogo morfogena gidry na uroben' beta-éndorfina i nekotorykh gormonov krovi i nadpochechnikov belykh krys.

The influence of PMH on the level of beta-endorphin and some hormones of blood and adrenal glands was studied. The dose A (10 mkg/kg) and dose W (100 mkg/kg) of PMH were used in our experiments. Earlier it has been discovered, that PMH in such doses stimulated the processes of cell division in 24 hours since the moment of injection. The stimulation was dose-dependent. Within 24 hours PMH in A dose decreased the concentration of beta-endorphin in the blood 2.7-fold, ad in dose W increased it 2 times. The level of corticosterone in blood and adrenal glands after the injection of PMH in dose A exceeded the control data trustworthy in 4 and 24 hours since the moment of injection. In dose B in 4 hours 1.5-fold reduction of corticosterone concentration took place in the blood. Increase in epinephrine level in adrenal glands was observed after PMH administration in two doses. Content of T3 increased in 4 hours after PMH injection in dose B. The role of hormonal changes in stimulating cell division accompanied by PMH injection is discussed. The data received show that PMH influences directly proliferative processes.

[Participation of peptide hydra morphogen in the regulation of proliferation processes in different tissues of white rats]. / Uchastie peptidnogo morfogena gidry v reguliatsii protsessov proliferatsii razlichnykh tkanei belykh krys.

The PMH influence on proliferation processes in some tissues of white rats was studied. PMH injections in doses 10.0 mkg/kg and 100.0 mkg/kg stimulated the processes of DNA--synthesis after 24 hours in corneal and tongue epithelium. The direct dose-dependent effect was revealed. PMH in dose 10.0 mkg/kg activated the proliferative processes in the stomach epithelium and thymus cortex. after 24 hours too. The given dose of PMH caused trustworthy decreasing of proliferative activity in thymus after 4 hours. The stimulation of DNA-synthesis and acceleration of mitosis were found after 5-times application on white rat's corneal with 100 nM PMH solution.

[Peptide hydra morphogen activates Na/H-exchange in human erythrocytes]. / Peptidnyi morfogen gidry aktiviruet Na/H-obmen v éritrotsitakh cheloveka.

The effect of peptide morphogen of hydra (PMH) on Na+/H+ exchange in human erythrocytes was studied. It was shown that this peptide leads to 2-7 fold activation of the rate of protons efflux from the human erythrocytes at concentration 100 nM. It was assumed, that peptide controls and regulates proliferation via the activation Na+/H+ exchange.

[Effects of undecapeptide hydra morphogen on processes of cell division in the corneal and tongue epithelium of white rats]. / Vliianie undekapeptida morfogena gidry na protsessy kletochnogo deleniia v épitelii rogovitsy i iazyka belykh krys.

We studied the effects of one and five time administration of peptide morphogen of hydra (PMH) in a dose of 10 micrograms/kg on cell division and DNA-synthesis in corneal and tongue epithelium of white rats. PMH stimulated cell proliferation considerably. This was revealed in acceleration of mitosis, and in rising of quantity of DNA-synthesis nuclei in 1.5-2.1 time after a single injection. In 24 hours after the five time administration the number of DNA-synthesis nuclei increased 1.5 and 1.9 time in corneal and tongue epithelium, correspondingly. This data reflects the possible role of PMH in structural homeostasis regulation.