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Exp Mol Pathol ; 81(1): 62-71, 2006 Aug.
Article in English | MEDLINE | ID: mdl-16765346

ABSTRACT

We report a case of acute lymphoblastic leukemia (ALL) with a 4;11 translocation. Metaphase cells and interphase nuclei derived from a routine unstimulated culture of bone marrow were analyzed using a combined strategy of G-banding and fluorescent in situ hybridization (FISH) in addition to hematopathological analysis, flow cytometry, and molecular genetics. This multimodal approach enables a successful correlation of pathology and cytogenetics to support a comprehensive diagnosis of the patient. Meaningful prognostication and appropriate therapeutic considerations are possible only when accurate diagnostic information is given. We further search and review the literature for the most up-to-date information currently available for this subtype of ALL in the constantly evolving field of molecular cytogenetics.


Subject(s)
Chromosomes, Human, Pair 11/genetics , Chromosomes, Human, Pair 4/genetics , Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis , Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics , Translocation, Genetic , Bone Marrow/pathology , Cytogenetics , Female , Flow Cytometry , Humans , In Situ Hybridization, Fluorescence , Middle Aged , Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology
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