Human exposure to formaldehyde and health risk assessment: a 46-year systematic literature review.

After confirming that formaldehyde (FA) is carcinogenic, many studies were conducted in different countries to investigate this finding. Therefore, according to the dispersion of related studies, a bibliometric review of the current literature was performed with the aim of better understanding the exposure to FA and the resulting health risk, for the first time, using the Scopus database and the two open-source software packages, Bibliometrix R package. After screening the documents in Excel, the data was analyzed based on three aspects including performance analysis, conceptual structure, and intellectual structure, and the results were presented in tables and diagrams. A total of 468 documents were analyzed over period 1977-2023, in which 1956 authors from 56 countries participated. The number of scientific publications has grown significantly from 1977 (n = 1) to 2022 (n = 19). Zhang Y., from the Yale School of Public Health (USA), was identified as the most impactful author in this field. The Science of the Total Environment journal was identified as the main source of articles related to exposure to formaldehyde by publishing 25 studies. The United States and China were the most active countries with the most international collaboration. The main topics investigated during these 46 years included "formaldehyde" and "health risk assessment", which have taken new directions in recent years with the emergence of the keyword "asthma". The present study provides a comprehensive view of the growth and evolution of studies related to formaldehyde and the resulting health risks, which can provide a better understanding of existing research gaps and new and emerging issues.

Burden of cardiovascular disease attributed to air pollution: a systematic review.

BACKGROUND: Cardiovascular diseases (CVDs) are estimated to be the leading cause of global death. Air pollution is the biggest environmental threat to public health worldwide. It is considered a potentially modifiable environmental risk factor for CVDs because it can be prevented by adopting the right national and international policies. The present study was conducted to synthesize the results of existing studies on the burden of CVDs attributed to air pollution, namely prevalence, hospitalization, disability, mortality, and cost characteristics. METHODS: A systematic search was performed in the Scopus, PubMed, and Web of Science databases to identify studies, without time limitations, up to June 13, 2023. Exclusion criteria included prenatal exposure, exposure to indoor air pollution, review studies, conferences, books, letters to editors, and animal and laboratory studies. The quality of the articles was evaluated based on the Agency for Healthcare Research and Quality Assessment Form, the Newcastle-Ottawa Scale, and Drummond Criteria using a self-established scale. The articles that achieved categories A and B were included in the study. RESULTS: Of the 566 studies obtained, based on the inclusion/exclusion criteria, 92 studies were defined as eligible in the present systematic review. The results of these investigations supported that chronic exposure to various concentrations of air pollutants, increased the prevalence, hospitalization, disability, mortality, and costs of CVDs attributed to air pollution, even at relatively low levels. According to the results, the main pollutant investigated closely associated with hypertension was PM2.5. Furthermore, the global DALY related to stroke during 2016-2019 has increased by 1.8 times and hospitalization related to CVDs in 2023 has increased by 8.5 times compared to 2014. CONCLUSION: Ambient air pollution is an underestimated but significant and modifiable contributor to CVDs burden and public health costs. This should not only be considered an environmental problem but also as an important risk factor for a significant increase in CVD cases and mortality. The findings of the systematic review highlighted the opportunity to apply more preventive measures in the public health sector to reduce the footprint of CVDs in human society.

Health risk assessment from inhalation exposure to indoor formaldehyde: A systematic review and meta-analysis.

This systematic review and meta-analysis investigated studies on formaldehyde (FA) inhalation exposure in indoor environments and related carcinogenic (CR) and non-carcinogenic (HQ) risk. Studies were obtained from Scopus, PubMed, Web of Science, Medline, and Embase databases without time limitation until November 21, 2023. Studies not meeting the criteria of Population, Exposure, Comparator, and Outcomes (PECO) were excluded. The 45 articles included belonged to the 5 types of sites: dwelling environments, educational centers, kindergartens, vehicle cabins, and other indoor environments. A meta-analysis determined the average effect size (ES) between indoor FA concentrations, CR, and HQ values in each type of indoor environment. FA concentrations ranged from 0.01 to 1620 µg/m3. The highest FA concentrations were stated in water pipe cafés and the lowest in residential environments. In more than 90% of the studies uncertain (1.00 ×10-6 1.00 ×10-4) due to FA inhalation exposure was reported and non-carcinogenic risk was stated acceptable. The meta-analysis revealed the highest CR values due to inhalation of indoor FA in high-income countries. As 90% of the time is spent indoors, it is crucial to adopt effective strategies to reduce FA concentrations, especially in kindergartens and schools, with regular monitoring of indoor air quality.

To breathe or not to breathe: Inhalational exposure to heavy metals and related health risk.

This study reviewed scientific literature on inhalation exposure to heavy metals (HMs) in various indoor and outdoor environments and related carcinogenic and non-carcinogenic risk. A systematic search in Web of Science, Scopus, PubMed, Embase, and Medline databases yielded 712 results and 43 articles met the requirements of the Population, Exposure, Comparator, and Outcomes (PECO) criteria. Results revealed that HM concentrations in most households exceeded the World Health Organization (WHO) guideline values, indicating moderate pollution and dominant anthropogenic emission sources of HMs. In the analyzed schools, universities, and offices low to moderate levels of air pollution with HMs were revealed, while in commercial environments high levels of air pollution were stated. The non-carcinogenic risk due to inhalation HM exposure exceeded the acceptable level of 1 in households, cafes, hospitals, restaurants, and metros. The carcinogenic risk for As and Cr in households, for Cd, Cr, Ni, As, and Co in educational environments, for Pb, Cd, Cr, and Co in offices and commercial environments, and for Ni in metros exceeded the acceptable level of 1 × 10-4. Carcinogenic risk was revealed to be higher indoors than outdoors. This review advocates for fast and effective actions to reduce HM exposure for safer breathing.

Climatic conditions and concentrations of BTEX compounds in atmospheric media.

Climatic and meteorological conditions are among the factors affecting the ambient concentrations of BTEX compounds. This systematic review and meta-analysis aimed to interrogate the seasonal effect of climatic conditions on the concentrations of BTEX compounds. Three electronic bibliographic databases including Scopus, PubMed, and Web of Science were systematically searched up to November 14, 2023. The search algorithm followed PRISMA guidance and consisted of three groupings of keywords and their possible combinations. For various climatic conditions, the overall mean and 95% confidence interval (CI) of effect size related to BTEX concentrations were calculated using a random-effect model. In total, 104 articles were included for evaluation in this review. BTEX ambient concentration was higher in winter (ranging from 36 out of 79 relevant studies for xylene to 52 out of 97 relevant studies for benzene) followed by summer and autumn. For humidity conditions, the highest exposure values for BTEX were detected for rainy weather (ranging from 3 out of 5 relevant studies for toluene and xylene to 4 out of 5 relevant studies for benzene and ethyl benzene) compared to dry conditions. The pooled concentration (µg/m3) of benzene, toluene, ethyl benzene, and xylene were computed as 2.61, 7.12, 2.21, and 3.61 in spring, 2.13, 7.53, 1.61, and 2.75 in summer, 3.04, 9.59, 3.14, and 5.50 in autumn, and 3.56, 8.71, 2.35, and 3.91 in winter, respectively. Moreover, the pooled concentrations (µg/m3) of BTEX were measured as 2.98, 7.22, 1.90, and 3.03 in dry weather and 3.15, 6.30, 2.14, and 3.86 in rainy or wet weather, respectively. In most seasons, the ambient concentrations of BTEX were higher in countries with low and middle incomes and in Middle Eastern countries and East/Southeast Asia compared to those in other regions (P < 0.001). The increasing concentrations of BTEX in winter and autumn followed by the summer season and during rainy/wet weather appear to be reasonably consistent despite variations in study methods, quality, or geography. Therefore, it is recommended that more serious control measures are considered for decreasing exposure to BTEX in these climatic conditions.

Occupational stress and musculoskeletal disorders in firefighters: the mediating effect of depression and job burnout.

The firefighting profession carries a heightened risk of musculoskeletal disorders. A firefighter's job is physically demanding and includes activities such as running, climbing, dragging, and lifting. Often, these tasks are unpredictable, performed in harsh environments, and have been found to cause psychological stress. The purpose of this study was to investigate the effects of occupational stress on work-related musculoskeletal disorders (WRMSD) in firefighters. In addition, the mediating effects of depression and job burnout on proposed relationships were examined. Data informing this study were collected using a survey questionnaire. The survey questionnaire included the Beck Depression Inventory, the Center for Epidemiological Studies Depression Scale (CES-D), the Maslach Burnout Inventory, the Post Traumatic Stress Disorder Inventory (PCL), and the Nordic Musculoskeletal Questionnaire. Collected data were analyzed using structural equation modeling approach in AMOS. The results of the 2339 responding firefighters suggest that work related stress is positively related to WRMSDs in firefighters and can lead to musculoskeletal symptoms through four paths, being emotional exhaustion, personal accomplishment, CES-D total score, and depersonalization. Through depersonalization, job stress had the most significant impact on musculoskeletal symptoms (coefficient = 0.053). Furthermore, the results showed that post-traumatic stress disorders (PTSD) can affect musculoskeletal symptoms through ten paths, again through depersonalization, PTSD had the most significant impact on musculoskeletal symptoms (coefficient = 0.141). The results of this study suggest that organizations should design interventions and policies to prevent and manage occupational stress, depression, and job burnout to negate its undesired consequences on firefighters' health (i.e. WRMSD).

Relationships between job stress, post-traumatic stress and musculoskeletal symptoms in firefighters and the role of job burnout and depression mediators: a bayesian network model.

INTRODUCTION: Job stress, post-traumatic stress disorder (PTSD), and negative psychological outcomes in firefighters can be caused, or aggravated, by their work. These mental disorders can impart musculoskeletal symptoms. This study aimed to investigate relationships between musculoskeletal and psychological disorders in a population of firefighters using a Bayesian network model. METHODS: This cross-sectional study, conducted in 2022, included 2339 firefighters who completed questionnaires during their rest periods. The questionnaires comprised of demographical information, the Occupational Stress Questionnaire-HSE, the PTSD Checklist, Maslach Burnout Inventory, Center for Epidemiologic Studies - Depression scale (CES-D), and Nordic Musculoskeletal Questionnaire. GeNIe academic software was used to analyze the Bayesian network. RESULTS: High job stress and high PTSD each increased the probability of musculoskeletal symptoms by 34%. When combined, high job stress and high PTSD increased the probability of musculoskeletal symptoms by 37%. Among the mediator's burnout and depression, depression had the highest association with musculoskeletal symptoms. CONCLUSIONS: Job stress and PTSD can increase musculoskeletal symptoms and are influenced by psychological mediators (like burnout and depression). Adopting preventive and therapeutic measures to mitigate job stress and PTSD, mitigate and rehabilitate WMSD, and manage associated mediators are critical for the mental and physical health of firefighters.

Health risk assessment of heavy metals in exposed workers of municipal waste recycling facility in Iran.

Exposure to heavy metals (HMs) present in the particulate matter from municipal solid waste during pretreatment and recycling processes may pose a serious health risk to workers. This was the first study on the exposure of municipal solid waste (MSW) recycling workers to toxic metals. The concentrations of HMs (Cd, Pb, As, Co, Cr, Ni, Cu, Fe, Mn, and Zn) during personal exposure to PM2.5 among municipal waste recycling facility workers in Kashan City, Iran, were investigated from January 15 to March 15, 2023. The research was performed in the three main stages of the waste recycling process: dismantling, sorting, and collecting. PM2.5 samples were collected using a personal environmental monitor (PEM) attached to a sampling pump. The non-carcinogenic and carcinogenic health risk values and related uncertainty for waste recyclers from HMs inhalational exposure were calculated using USEPA methodology and Monte Carlo simulations. The results showed that the dismantlers exhibited the highest exposure concentrations of PM2.5 (mean 2148 ± 1257 µg m-3), followed by sorters (mean 1864 ± 965 µg m-3), and collectors (mean 1782 ± 876 µg m-3). Health risk assessment indicated that 95th percentile contents of Ni, As, Co, and Zn were responsible for the non-carcinogenic risk (HQ) values exceeding the acceptable level of 1. The contents of As, Ni, and Cr in PM2.5 caused a non-acceptable carcinogenic risk for waste recyclers due to inhalational exposure, as the carcinogenic risk (CR) values exceeded the acceptable threshold of 1 × 10-6. Monte Carlo simulation results revealed that the mean and median CR values from inhalational exposure to carcinogenic HMs exceeded the acceptable level of 1 × 10-6 for municipal waste recyclers. As results of this study indicated the high-risk to hazardous metals for waste recyclers due to occupational exposure in the MSW recycling sites, it is suggested to consider workers' exposure as the public health concern.

The global prevalence of musculoskeletal disorders among firefighters: a systematic review and meta-analysis.

This systematic review and meta-analysis study aimed to explore the global prevalence of musculoskeletal disorders (MSDs) among firefighters. A systematical search was performed in three international academic databases (Scopus, PubMed and Web of Science). Overall, 31 articles were included in this review. The pooled prevalence of total MSDs in firefighters was identified as 41% (95% confidence interval [CI] [33, 50]). The prevalence of MSDs in neck, shoulders, upper back, lower back, upper extremity and lower extremity was 9% (95% CI [7, 10]), 11% (95% CI [8, 15]), 8% (95% CI [5, 12]), 31% (95% CI [27, 34]), 13% (95% CI [9, 17]) and 16% (95% CI [14, 18]), respectively. No statistically significant relationship was observed between prevalence of MSDs and year of study, mean age, size of sample, duration of prevalence, region or income level. Demographic, occupational and medical condition factors were identified that can create these disorders among firefighters.

Human exposure to heavy metals and related cancer development: a bibliometric analysis.

As notifications on carcinogenicity of heavy metals increase, more and more attention is paid recently to heavy metals exposure. In our study, the human exposure to heavy metals and cancer knowledge epistemology was investigated using bibliometric analysis. The bibliometric data of the research articles were retrieved using following keywords: "heavy metal," "trace element", "cancer", "carcinogen", and "tumor" in the Scopus database. Specifically, 2118 articles published between 1972 and 2023 were found, covering a total of 1473 authors, 252 sources, and 2797 keywords. Retrospective data obtained from 251 documents and 145 journals were further analyzed by performance analysis and techniques of science mapping. The number of studies conducted in this field increased from one article published in 1972 to 18 articles published in 2022 in the study of Michael P Waalkes. The most impactful author regarding the number of published papers was Masoudreza Sohrabi with 7 publications. In the majority of the published papers, the most popular keywords were "cadmium" and "carcinogenicity". However, in recent 4 years, the emphasis has been placed more on epidemiology studies. Our study provides general knowledge about the trend of publication on the role of heavy metals in causing cancer. The leading researchers in the field of the effects of heavy metals on the development of cancer were identified in our studies. Our results might also create a better understanding of new and emerging issues and can be used as a comprehensive road map for future researchers.

Blood-lead level in humans and drug addiction: a comprehensive study in Iran.

Drug abuse has a high prevalence worldwide and causes many health-related disorders. There are limited human exposure studies on establishing lead exposure levels and their propensity for drug addiction. In the present study, blood samples were tested for lead (Pb) concentrations in illicit drug users together with the related symptoms in comparison with control group of non-drug users. The study was performed on 250 volunteers divided equally in four drug groups, namely, opioids, hashish, methadone, and methamphetamine, and one control group of non-drug users. Participants were recruited from drug addiction clinics and camps in Kashan city, Iran, who were using drugs continuously for more than 1 year. Control group was recruited from companions of the patients with no drug use history. In the investigated groups of drug users, the highest blood-lead level (BLL) concentrations were observed in the opioid group (mean 37.57 µg/dL) with almost 3.7 times higher than in the control group (mean 3.39 µg/dL). In the methamphetamine group, type of occupation had the significant association with BLL concentrations. The positive correlation was revealed in the opioid and methadone groups for BLL concentrations and the duration of drug usage. In the opioid group, the highest BLL concentrations were observed among users who used both methods of drug use: smoking and eating. Also, several behavioral and life-style factors were identified which influence the blood-lead concentration in the drug users. The results of our study revealed that the BLL concentrations in investigated drug users' groups were significantly higher than in the control group (P < 0.001). That can be related with the Pb contents in illicitly used drugs. Apart other adverse health effects, long-term illicit drug use might cause to lead poisoning.

The effects of occupational noise on sleep: A systematic review.

Noise exposure in the workplace is one of the most common occupational hazards, which can affect sleep in the human. The effects of occupational noise can be different than that of environmental or social noise. This study aimed to conduct a systematic review on the effects of occupational noise on various characteristics of sleep. In this study, three electronic bibliographic databases (Scopus, PubMed, and Web of Science) were systematically searched up to 14 December 2022. The search algorithm included two sets of keywords and possible combinations. The first group was keywords related to occupational noise, and the second group was keywords related to sleep. A total of 2082 articles were identified in the initial search, and 2034 articles were excluded based on exclusion criteria or lacking inclusion criteria. Finally, 48 articles met the inclusion criteria and were selected for final review. Among 13 articles identified as high quality, all studies (100%) showed that noise had a significant effect on sleep among workers in various occupations. Among 17 articles with moderate quality, thirteen studies (76.47%) indicated that noise had a significant effect on sleep among workers in different occupations. Among 18 low-quality articles, fifteen studies (83.33%) showed that noise had a significant effect on sleep. 41 out of 48 studies (85.42%) found that occupational noise can negatively impact sleep among employees in various occupations. There are at least four potential pathways for this effect, including the physiological effect of daytime noise exposure, the psychological effect of daytime noise exposure, the effect of nighttime noise exposure, and the effect of hearing problems due to noise.

Providing an approach to analyze the risk of central oxygen tanks in hospitals during the COVID-19 pandemic.

The central oxygen unit of hospitals is considered a high-risk unit, requiring high safety standards to maintain the integrity of the system during the COVID-19 pandemic. The linear reasoning assumption of conventional risk analysis methods cannot adequately describe these modern systems, which are characterized by tight connections and complex interactions between technical, human, and organizational aspects. Therefore, this study presents a new and comprehensive approach to oxygen tanks in hospitals during the COVID-19 pandemic. In this study, trapezoidal fuzzy numbers were used to calculate failure rates. After determining the probability of basic events (BEs), intermediate events (IE), and top event (TE) with fuzzy logic and transferring it into Bayesian Network (BN), deductive and inductive reasoning, and sensitivity analysis were performed using RoV in GeNIe software. The results of the case study showed that the IE of "Human Error" had the highest probability of fuzzy fault tree (FFT) and the probability of oxygen leakage was lower using FBN than FFT. According to the results, BE16 (failure to use standard and updated instructions) and BE12 (defects in the inspection and testing program of tank devices) had the highest posterior probability, while based on the FFT results, BE4 (defects in the external coating system of the tank) and, BE3 (Corrosive environment (acidity state)) had the least probability. According to the sensitivity analysis, basic events 10, 11, and 16 were the most important in the oxygen leakage event with a very small difference, which was almost in line with the results of posterior FBN (FBNPO). Updating the existing guidelines, fixing defects in the inspection of all types of tank gauges, and testing related equipment can greatly help the reliability of these tanks. Root cause analysis of these events provides opportunities for prevention and emergency response in critical situations, such as the COVID-19 pandemic.

Health risk assessment of exposure to various vapors and fumes in a factory of automobile manufacturing.

This study aimed to comprehensively evaluate the health risk of exposure to various vapors and fumes in a factory of automobile manufacturing. This study was performed in 2021 on 115 workers. Vapors and fumes were gathered by the adsorbent tubes of activated charcoal and mixed cellulose esters (MCE) membrane filter, respectively. The flow rate for vapors and fumes were between 0.05 and 0.20 L per min and 1 to 4 L per min, respectively. After preparing, samples were analyzed. To assess the non-cancer and cancer risk of the pollutants, the method proposed environmental protection agency (EPA) was applied. The total concentration of copper (1.031 ppm), manganese (0.114), and 2-butoxyethanol (91.767 ppm) were found to be higher than The threshold limit values (TLVs). The values of non-cancer risk (HQ) due to exposure to vapors of benzene (6.583), toluene (1.396), ethyl benzene (1.212), xylene (31.148), 2-butoxyethanol (89.302), 2-propanol (4.695), 1,2,3-trimethylbenzene (1.923), copper (2.336), manganese (715.82), aluminum (3.772), and chromium (107.066) were higher than the acceptable limit. Moreover, the estimated LCR for benzene (2.15 × 10-4), ethyl benzene (3.97 × 10-4), vinyl chloride (1.25 × 10-4), and chromium (2.11 × 10-2) were higher than the threshold risk level set by EPA. It is emphasized that preventive measures are performed.

Summer and winter variations of BTEX concentrations in an oil refinery complex and health risk assessment based on Monte-Carlo simulations.

The summer and winter concentrations of BTEX pollutants were investigated in various workplaces of an oil Refinery, Iran. In total 252 air samples from the breathing zones of the following employees were collected: supervisors, safetymen, repairmen, site men, and all workers. Carcinogenic and non-carcinogenic risk values were calculated based on the USEPA methodology using Monte Carlo simulations. BTEX concentrations were higher in the summer than in the winter season for all workstations, especially for toluene and ethylbenzene. The mean values of exposure to benzene for repairmen and site men were higher than threshold limit value of 1.60 mg/m3 for both seasons. Non-carcinogenic risk (HQ) values calculated for summer season for benzene, ethylbenzene, and xylene in all workstations, as well as for toluene for repairmen and site men exceeded acceptable level of 1. In winter season the mean HQ values for benzene and xylene in all workstations, for toluene for repairmen and site men, and for ethylbenzene for supervisors, repairmen, and site men were also > 1. For all workstations definite carcinogenic risk was indicated as calculated LCR values for benzene and ethylbenzene exposure were higher than 1 × 10-4 in both summer and winter seasons.

Performance assessment of the MOF adsorbent MIL-101 for removal of gaseous benzene and toluene: kinetic column modeling and simulation studies of fixed-bed adsorption.

The adsorbent MIL-101, a metal-organic framework material, was synthesized, characterized, and tested for removal of relatively low concentrations of benzene and toluene adsorbates (200 ppm) from a gas phase in a continuous flow system. Breakthrough studies were modeled based on Thomas, Yoon-Nelson, Yan, Clark, Bohart-Adams, bed-depth service time, modified dose response, Wolborska, and Gompertz in the continuous fixed-bed operation. Through statistical analysis, it was determined which type of regression is most suitable for the studied models, linear or nonlinear. By comparing the values of error functions, it was possible to infer that the Thomas model is the best match for the experimental breakthrough curves for benzene (with maximum solid-phase concentration qT=126,750 mg/g) and the Gompertz model for toluene (parameter ß=0.01 min-1). Overall, when compared to the model parameters of the linear regression, those obtained through nonlinear regression show a stronger correlation with the results found experimentally. Thus, this type of regression is more suitable for the adsorption model analysis. The liquid film and intraparticle diffusion analysis was described, and it was suggested that both types of diffusion contribute to the adsorption mechanism of benzene and toluene on MIL-101. As for the isotherms, the adsorption process was better fitted by the Freundlich isotherm. The reusability of MIL-101 after six cycles was 76.5% for benzene and 62.4% for toluene, indicating that MIL-101 was a better adsorbent for the removal of benzene in comparison with toluene.

Critical air pollutant assessments and health effects attributed to PM2.5 during and after COVID-19 lockdowns in Iran: application of AirQ+ models.

Objectives: The aim of this study was to evaluate changes in air quality index (AQI) values before, during, and after lockdown, as well as to evaluate the number of hospitalizations due to respiratory and cardiovascular diseases attributed to atmospheric PM2.5 pollution in Semnan, Iran in the period from 2019 to 2021 during the COVID-19 pandemic. Methods: Daily air quality records were obtained from the global air quality index project and the US Environmental Protection Administration (EPA). In this research, the AirQ+ model was used to quantify health consequences attributed to particulate matter with an aerodynamic diameter of <2.5 µm (PM2.5). Results: The results of this study showed positive correlations between air pollution levels and reductions in pollutant levels during and after the lockdown. PM2.5 was the critical pollutant for most days of the year, as its AQI was the highest among the four investigated pollutants on most days. Mortality rates from chronic obstructive pulmonary disease (COPD) attributed to PM2.5 in 2019-2021 were 25.18% in 2019, 22.55% in 2020, and 22.12% in 2021. Mortality rates and hospital admissions due to cardiovascular and respiratory diseases decreased during the lockdown. The results showed a significant decrease in the percentage of days with unhealthy air quality in short-term lockdowns in Semnan, Iran with moderate air pollution. Natural mortality (due to all-natural causes) and other mortalities related to COPD, ischemic heart disease (IHD), lung cancer (LC), and stroke attributed to PM2.5 in 2019-2021 decreased. Conclusion: Our results support the general finding that anthropogenic activities cause significant health threats, which were paradoxically revealed during a global health crisis/challenge.

Inhalational exposure to formaldehyde, carcinogenic, and non-carcinogenic risk assessment: A systematic review.

Formaldehyde is one of the most widely used substances in a variety of industries, although it was classified as a human carcinogen by the International Agency for Research on Cancer (IARC). The present systematic review was conducted to retrieve studies related to occupational exposure to formaldehyde until November 2, 2022. Aims of the study were to identify workplaces exposed to formaldehyde, to investigate the formaldehyde concentrations in various occupations and to evaluate carcinogenic and non-carcinogenic risks caused by respiratory exposure to this chemical among workers. A systematic search was done in Scopus, PubMed and Web of Science databases to find the studies done in this field. In this review, studies that did not meet the criteria specified by Population, Exposure, Comparator, and Outcomes (PECO) approach were excluded. In addition, the inclusion of studies dealing with the biological monitoring of FA in the body and review studies, conference articles, books, and letters to the editors were avoided. The quality of the selected studies was also evaluated using the Joanna Briggs Institute (JBI) checklist for analytic-cross-sectional studies. Finally, 828 studies were found, and after the investigations, 35 articles were included in this study. The results revealed that the highest formaldehyde concentrations were observed in waterpipe cafes (1,620,000 µg/m3) and anatomy and pathology laboratories (4237.5 µg/m3). Carcinogenic and non-carcinogenic risk indicated the potential health effects for employees due to respiratory exposure as acceptable levels of CR = 1.00 × 10-4 and HQ = 1, respectively were reported to be exceeded in more than 71% and 28.57% of the investigated studies. Therefore, according to the confirmation of formaldehyde's adverse health effects, it is necessary to adopt targeted strategies to reduce or eliminate exposure to this compound from the occupational usage.

Development and validation of a biological risk assessment tool among hospital personnel under COVID-19 pandemic conditions.

The need for a biological disease risk assessment method to prevent the contagion of these diseases, particularly among healthcare personnel, is crucial. Therefore, this study aimed to develop and validate a biological risk assessment tool for biological agents among hospital personnel under COVID-19 conditions. This cross-sectional study was performed on 301 employees in two hospitals. Firstly, we identified the items affecting the contagion of biological agents. Then, we computed the weight of the items using the Fuzzy Analytical Hierarchy Process (FAHP) method. We used the identified items and the estimated weights in the next step to develop a predictive equation. The outcome of this tool was the risk score of biological disease contagion. After that, we used the developed method to evaluate the biological risk of the participants. The ROC curve was also used to reveal accuracy of developed method. In this study, 29 items were identified and categorized into five dimensions, including environmental items, ventilation items, job items, equipment-related items, and organizational items. The weights of these dimensions were estimated at 0.172, 0.196, 0.255, 0.233, and 0.144, respectively. The final weight of items was used to develop a predictive equation. The area under ROC curves (AUC) was also calculated as 0.762 (95% CI: 0.704, 0.820) (p<0.001). The tools developed using these items had acceptable diagnostic accuracy for predicting the risk of biological diseases in health care. Therefore, one can apply it in identifying persons exposed to dangerous conditions.

Examining the effect of safety climate on accident risk through job stress: a path analysis.

BACKGROUND: Job stress is a probable mediator of the relationship between safety climate and accident occurrence. To demonstrate this, this study investigates the relationship between safety climate, job stress, and accident risk using a large number of surveys. The study will use structural equation modeling (SEM) to analyze the data collected from the surveys to examine the effect of safety climate on accident risk through job stress. METHODS: The study is a cross-sectional study that was conducted on 1,530 male workers of a petrochemical company. The subjects were asked to complete several questionnaires during rest periods, which included demographic information, the Nordic safety climate questionnaire (NOSACQ-50), and the generic job stress questionnaire (GJSQ). Additionally, data on the frequency and intensity of accidents among participants were gathered from the health unit of the company. Path analysis was conducted by structural equation modeling (SEM) in Analysis of Moment Structures (AMOS) software. RESULTS: The results revealed that the latent variable of safety climate with an effect coefficient of - 0.112 did not have a direct effect on accident risk (P = 0.343). However, safety climate with an effect coefficient of - 0.633 had an indirect effect on accident risk through job stress (P < 0.001). The total score of job stress had a significant direct effect (0.649) on accident risk (P < 0.001). Among the dimensions of safety climate, the variables of management's safety priority, commitment, and competence (- 0.108) and workers' safety commitment (- 0.107) had the highest indirect effect coefficients on accident risk. Among the dimensions of job stress, the highest indirect effects belonged to the variables of conflict at work (0.636), physical environment (0.631), and workload and responsibility (0.631), respectively. CONCLUSION: The results of the study revealed that job stress mediates the relationship between safety climate and accident risk. This finding suggests that organizations can potentially decrease accidents in industries by addressing and managing job stress in the workplace.